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Cellosaurus EA.hy 926 (CVCL_3901)

[Text version]

Cell line name EA.hy 926
Synonyms EA. hy 926; EA hy 926; EAhy 926; EAHY-926; EA.Hy926; EA.hy926; EAhy926; EaHy926; Eahy926
Accession CVCL_3901
Resource Identification Initiative To cite this cell line use: EA.hy 926 (RRID:CVCL_3901)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Produced by the fusion of A549/8 with human umbilical vein endothelial cells.
Doubling time: 12 hours (PubMed=6407019).
Omics: Transcriptome analysis.
Anecdotal: Have been flown in space on Shijian-10 and on the ISS in 2016 to study growth and secretion in microgravity (PubMed=28199884; PubMed=30108515; PubMed=30977987).
Misspelling: EA.hy 296; Occasionally.
Misspelling: EA-hy 296; Occasionally.
Misspelling: EA.hy296; Occasionally.
Sequence variations Homozygous for KRAS p.Gly12Ser (c.34G>A) (ClinVar=VCV000012584) (from parent cell line).
Homozygous for STK11 p.Gln37Ter (c.109C>T) (ClinVar=VCV000376334) (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IY87 (A549/8)
Sex of cell Male
Category Hybrid cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,11,12
D5S81811
D7S8208,9,10
D13S31711
D16S53911,12
TH016,8,9.3
TPOX8,9
vWA14,17

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=1660
http://www.cellresource.cn/fdetail.aspx?id=2148
Publications

PubMed=6407019; DOI=10.1073/pnas.80.12.3734
Edgell C.-J.S., McDonald C.C., Graham J.B.
Permanent cell line expressing human factor VIII-related antigen established by hybridization.
Proc. Natl. Acad. Sci. U.S.A. 80:3734-3737(1983)

PubMed=3130908; DOI=10.1182/blood.V71.6.1669.1669
Emeis J.J., Edgell C.-J.S.
Fibrinolytic properties of a human endothelial hybrid cell line (Ea.hy 926).
Blood 71:1669-1675(1988)

PubMed=7791520; DOI=10.1016/0024-3205(95)00227-W
Ahn K., Pan S., Beningo K., Hupe D.
A permanent human cell line (EA.hy926) preserves the characteristics of endothelin converting enzyme from primary human umbilical vein endothelial cells.
Life Sci. 56:2331-2341(1995)

PubMed=12453433; DOI=10.1006/mvre.2002.2434
Unger R.E., Krump-Konvalinkova V., Peters K., Kirkpatrick C.J.
In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R.
Microvasc. Res. 64:384-397(2002)

PubMed=16575254; DOI=10.1097/01.mbc.0000220237.99843.a1
Boerma M., Burton G.R., Wang J., Fink L.M., McGehee R.E. Jr., Hauer-Jensen M.
Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition.
Blood Coagul. Fibrinolysis 17:173-180(2006)

PubMed=28199884; DOI=10.1016/j.biomaterials.2017.02.005
Pietsch J., Gass S., Nebuloni S., Echegoyen D., Riwaldt S., Baake C., Bauer J., Corydon T.J., Egli M., Infanger M., Grimm D.
Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission -- The SPHEROIDS project.
Biomaterials 124:126-156(2017)

PubMed=30108515; DOI=10.3389/fphys.2018.01025
Li N., Wang C.-Z., Sun S.-J., Zhang C., Lu D.-Y., Chen Q., Long M.
Microgravity-induced alterations of inflammation-related mechanotransduction in endothelial cells on board SJ-10 satellite.
Front. Physiol. 9:1025-1025(2018)

PubMed=30977987; DOI=10.33594/000000071
Kruger M., Pietsch J., Bauer J., Kopp S., Carvalho D.T.O., Baatout S., Moreels M., Melnik D., Wehland M., Egli M., Jayashree S., Kobbero S.D., Corydon T.J., Nebuloni S., Gass S., Evert M., Infanger M., Grimm D.
Growth of endothelial cells in space and in simulated microgravity -- a comparison on the secretory level.
Cell. Physiol. Biochem. 52:1039-1060(2019)

Cross-references
Cell line collections ATCC; CRL-2922
BCRJ; 0345
KCB; KCB 2014048YJ
NCBI_Iran; C641
Cell line databases/resources CCRID; 3111C0001CCC000475
CCRID; 3131C0001000200039
Lonza; 685
Ontologies BTO; BTO:0000396
EFO; EFO_0003039
Biological sample resources BioSample; SAMN03471700
Gene expression databases GEO; GSM46371
GEO; GSM46380
GEO; GSM46382
GEO; GSM46383
GEO; GSM46384
GEO; GSM46385
GEO; GSM46392
GEO; GSM46393
Other Wikidata; Q54831722
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number20