ID   EA.hy 926
AC   CVCL_3901
SY   EA. hy 926; EA hy 926; EA-hy926; EAhy 926; EAHY-926; EA.Hy926; EA.hy926; EAhy926; EaHy926; Eahy926
DR   BTO; BTO:0000396
DR   EFO; EFO_0003039
DR   ATCC; CRL-2922
DR   BCRJ; 0345
DR   BioSample; SAMN03471700
DR   CCRID; 1101HUM-PUMC000475
DR   CCRID; 3101HUMGNHu39
DR   Cell_Model_Passport; SIDM01986
DR   ChEMBL-Cells; CHEMBL4295452
DR   ChEMBL-Targets; CHEMBL4296410
DR   CLS; 305034
DR   GEO; GSM46371
DR   GEO; GSM46380
DR   GEO; GSM46382
DR   GEO; GSM46383
DR   GEO; GSM46384
DR   GEO; GSM46385
DR   GEO; GSM46392
DR   GEO; GSM46393
DR   KCB; KCB 2014048YJ
DR   Lonza; 685
DR   NCBI_Iran; C641
DR   PubChem_Cell_line; CVCL_3901
DR   Ubigene; YC-C032
DR   Wikidata; Q54831722
RX   PubMed=3130908;
RX   PubMed=6407019;
RX   PubMed=7791520;
RX   PubMed=12453433;
RX   PubMed=16575254;
RX   PubMed=26345505;
RX   PubMed=28199884;
RX   PubMed=30108515;
RX   PubMed=30977987;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Produced by the fusion of A549/8 with human umbilical vein endothelial cells.
CC   Doubling time: 12 hours (PubMed=6407019).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Anecdotal: Have been flown in space on Shijian-10 and on the ISS in 2016 to study growth and secretion in microgravity (PubMed=28199884; PubMed=30108515; PubMed=30977987).
CC   Misspelling: EA.hy 296; Note=Occasionally.
CC   Misspelling: EA-hy 296; Note=Occasionally.
CC   Misspelling: EA.hy296; Note=Occasionally.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 10,11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 11
ST   D7S820: 8,9,10
ST   TH01: 6,8,9.3
ST   TPOX: 8,9
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_IY87 ! A549/8
SX   Male
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   PubMed=3130908; DOI=10.1182/blood.V71.6.1669.1669;
RA   Emeis J.J., Edgell C.-J.S.;
RT   "Fibrinolytic properties of a human endothelial hybrid cell line
RT   (Ea.hy 926).";
RL   Blood 71:1669-1675(1988).
//
RX   PubMed=6407019; DOI=10.1073/pnas.80.12.3734;
RA   Edgell C.-J.S., McDonald C.C., Graham J.B.;
RT   "Permanent cell line expressing human factor VIII-related antigen
RT   established by hybridization.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:3734-3737(1983).
//
RX   PubMed=7791520; DOI=10.1016/0024-3205(95)00227-W;
RA   Ahn K., Pan S., Beningo K., Hupe D.;
RT   "A permanent human cell line (EA.hy926) preserves the characteristics
RT   of endothelin converting enzyme from primary human umbilical vein
RT   endothelial cells.";
RL   Life Sci. 56:2331-2341(1995).
//
RX   PubMed=12453433; DOI=10.1006/mvre.2002.2434;
RA   Unger R.E., Krump-Konvalinkova V., Peters K., Kirkpatrick C.J.;
RT   "In vitro expression of the endothelial phenotype: comparative study
RT   of primary isolated cells and cell lines, including the novel cell
RT   line HPMEC-ST1.6R.";
RL   Microvasc. Res. 64:384-397(2002).
//
RX   PubMed=16575254; DOI=10.1097/01.mbc.0000220237.99843.a1;
RA   Boerma M., Burton G.R., Wang J.-R., Fink L.M., McGehee R.E. Jr.,
RA   Hauer-Jensen M.;
RT   "Comparative expression profiling in primary and immortalized
RT   endothelial cells: changes in gene expression in response to hydroxy
RT   methylglutaryl-coenzyme A reductase inhibition.";
RL   Blood Coagul. Fibrinolysis 17:173-180(2006).
//
RX   PubMed=26345505; DOI=10.2144/000114326;
RA   Lieber D., Hochdorfer D., Stoehr D., Schubert A., Lotfi R., May T.,
RA   Wirth D., Sinzger C.;
RT   "A permanently growing human endothelial cell line supports productive
RT   infection with human cytomegalovirus under conditional cell growth
RT   arrest.";
RL   BioTechniques 59:127-136(2015).
//
RX   PubMed=28199884; DOI=10.1016/j.biomaterials.2017.02.005;
RA   Pietsch J., Gass S., Nebuloni S., Echegoyen D., Riwaldt S., Baake C.,
RA   Bauer J., Corydon T.J., Egli M., Infanger M., Grimm D.;
RT   "Three-dimensional growth of human endothelial cells in an automated
RT   cell culture experiment container during the SpaceX CRS-8 ISS space
RT   mission -- the SPHEROIDS project.";
RL   Biomaterials 124:126-156(2017).
//
RX   PubMed=30108515; DOI=10.3389/fphys.2018.01025;
RA   Li N., Wang C.-Z., Sun S.-J., Zhang C., Lu D.-Y., Chen Q., Long M.;
RT   "Microgravity-induced alterations of inflammation-related
RT   mechanotransduction in endothelial cells on board SJ-10 satellite.";
RL   Front. Physiol. 9:1025.1-1025.15(2018).
//
RX   PubMed=30977987; DOI=10.33594/000000071;
RA   Kruger M., Pietsch J., Bauer J., Kopp S., Carvalho D.T.O., Baatout S.,
RA   Moreels M., Melnik D., Wehland M., Egli M., Sahana J., Kobbero S.D.,
RA   Corydon T.J., Nebuloni S., Gass S., Evert M., Infanger M., Grimm D.;
RT   "Growth of endothelial cells in space and in simulated microgravity --
RT   a comparison on the secretory level.";
RL   Cell. Physiol. Biochem. 52:1039-1060(2019).
//