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Cellosaurus T24T SLT4 (CVCL_3922)

[Text version]
Cell line name T24T SLT4
Synonyms SLT4; SL4
Accession CVCL_3922
Resource Identification Initiative To cite this cell line use: T24T SLT4 (RRID:CVCL_3922)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Population: Caucasian; Swedish.
Characteristics: Forms metastasis in the liver of mice. Produced by passage of the parent cell line through nude mice.
Omics: Exosome proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_RN65 (T24T SL3)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Publications

PubMed=19147813; DOI=10.2353/ajpath.2009.080538
Smith S.C., Nicholson B., Nitz M.D., Frierson H.F. Jr., Smolkin M., Hampton G.M., El-Rifai W., Theodorescu D.
Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination.
Am. J. Pathol. 174:371-379(2009)

PubMed=24376083; DOI=10.1002/pmic.201300452
Jeppesen D.K., Nawrocki A., Jensen S.G., Thorsen K., Whitehead B., Howard K.A., Dyrskjot L., Orntoft T.F., Larsen M.R., Ostenfeld M.S.
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics 14:699-712(2014)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3922
Anatomy/cell type resources BTO; BTO:0004892
Encyclopedic resources Wikidata; Q54971478
Gene expression databases GEO; GSM136257
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number16