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Cellosaurus CEM/VLB100 (CVCL_3932)

[Text version]

Cell line name CEM/VLB100
Synonyms CEM-VLB100; CEM/VLB 100; CEM/VBL 100; CEM-VBL100
Accession CVCL_3932
Resource Identification Initiative To cite this cell line use: CEM/VLB100 (RRID:CVCL_3932)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27375; Vincaleukoblastine (Vinblastine).
Caution: Seems to be interchangeably called VLB100 or VBL100.
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=571759
Beck W.T., Mueller T.J., Tanzer L.R.
Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.
Cancer Res. 39:2070-2076(1979)

PubMed=2888532
Beck W.T., Cirtain M.C., Danks M.K., Felsted R.L., Safa A.R., Wolverton J.S., Suttle D.P., Trent J.M.
Pharmacological, molecular, and cytogenetic analysis of 'atypical' multidrug-resistant human leukemic cells.
Cancer Res. 47:5455-5460(1987)

PubMed=3469013
Danks M.K., Yalowich J.C., Beck W.T.
Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).
Cancer Res. 47:1297-1301(1987)

PubMed=9557624; DOI=10.1038/sj.leu.2400976
Mattii L., Barale R., Petrini M.
Use of the comet test in the evaluation of multidrug resistance of human cell lines.
Leukemia 12:627-632(1998)

Cross-references
Anatomy/cell type resources BTO; BTO:0005155
Encyclopedic resources Wikidata; Q54809282
Polymorphism and mutation databases Cosmic; 922676
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number23