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Cellosaurus WEHI-7.2 (CVCL_3950)

Cell line name WEHI-7.2
Synonyms WEHI 7.2; WEHI7.2
Accession CVCL_3950
Resource Identification Initiative To cite this cell line use: WEHI-7.2 (RRID:CVCL_3950)
Comments Characteristics: Treatment with dexamethasone, a synthetic glucocorticoid, causes the cells to undergo apoptosis (PubMed=17180014).
Doubling time: 13.78 +- 0.38 hours (PubMed=11526450).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
Disease Mouse thymoma (NCIt: C198577)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_F526 (WEHI-7)
Children:
CVCL_C7PV (W.Hb12)CVCL_C7PW (W.Hb13)CVCL_C7PX (WEHI-7.2 100R)
CVCL_C7PY (WEHI-7.2 200R)CVCL_C7PZ (WEHI-7.2 50R)CVCL_C7PR (WEHI-7.2 CAT2)
CVCL_C7PS (WEHI-7.2 CAT38)CVCL_C7PT (WEHI-7.2 Trx5)CVCL_C7PU (WEHI-7.2 Trx6)
Category Cancer cell line
Publications

PubMed=8022822; DOI=10.1073/pnas.91.14.6569
Lam M., Dubyak G.R., Chen L., Nunez G., Miesfeld R.L., Distelhorst C.W.
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.
Proc. Natl. Acad. Sci. U.S.A. 91:6569-6573(1994)

PubMed=17180014
Briehl M.M., Cotgreave I.A., Powis G.
Downregulation of the antioxidant defence during glucocorticoid-mediated apoptosis.
Cell Death Differ. 2:41-46(1995)

PubMed=9371519
Baker A., Payne C.M., Briehl M.M., Powis G.
Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.
Cancer Res. 57:5162-5167(1997)

PubMed=11289160
Tome M.E., Baker A.F., Powis G., Payne C.M., Briehl M.M.
Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growth.
Cancer Res. 61:2766-2773(2001)

PubMed=11526450; DOI=10.1038/sj.cdd.4400904
Tome M.E., Briehl M.M.
Thymocytes selected for resistance to hydrogen peroxide show altered antioxidant enzyme profiles and resistance to dexamethasone-induced apoptosis.
Cell Death Differ. 8:953-961(2001)

PubMed=12203227; DOI=10.1002/nbm.790
Lutz N.W., Tome M.E., Aiken N.R., Briehl M.M.
Changes in phosphate metabolism in thymoma cells suggest mechanisms for resistance to dexamethasone-induced apoptosis. A 31P NMR spectroscopic study of cell extracts.
NMR Biomed. 15:356-366(2002)

PubMed=15702245; DOI=10.3892/ijmm.15.3.497
Tome M.E., Briehl M.M., Lutz N.W.
Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile.
Int. J. Mol. Med. 15:497-501(2005)

Cross-references
Cell line databases/resources Lonza; 1003
Anatomy/cell type resources BTO; BTO:0003181
Encyclopedic resources Wikidata; Q54993771
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number9