Home  |  Contact

Cellosaurus LN-235 (CVCL_3957)

[Text version]

Cell line name LN-235
Synonyms LN 235; LN235
Accession CVCL_3957
Resource Identification Initiative To cite this cell line use: LN-235 (RRID:CVCL_3957)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 37 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Sequence variations TP53 p.Cys176Ser (c.526T>A) (PubMed=10416987).
Homozygous for TP53 p.Tyr163Cys (c.488A>G) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.32
Native American0.31
East Asian, North4.46
East Asian, South0
South Asian3.28
European, North23.54
European, South65.09
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): PubMed=22570425

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815,17
D5S81811,12
D7S82010,12
D8S117914,15
D13S3179
D16S53911
D18S5113,16
D21S1129,32.2
FGA22
Penta D11,12
Penta E14,15
TH017,9
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2990147; DOI=10.1007/BF00688585
Studer A., de Tribolet N., Diserens A.-C., Gaide A.-C., Matthieu J.-M., Carrel S., Stavrou D.
Characterization of four human malignant glioma cell lines.
Acta Neuropathol. 66:208-217(1985)

PubMed=7693337
Li H., Hamou M.-F., de Tribolet N., Jaufeerally R., Hofmann M., Diserens A.-C., Van Meir E.G.
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Cancer Res. 53:5345-5349(1993)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources CCLE; LN235_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM01367
DepMap; ACH-000591
Ontologies BTO; BTO:0004448
Biological sample resources BioSample; SAMN10988392
Other Wikidata; Q54902773
Polymorphism and mutation databases Cosmic; 849862
Cosmic; 2367491
Cosmic; 2516026
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number12