ID   LN-235
AC   CVCL_3957
SY   LN 235; LN235
DR   BTO; BTO:0004448
DR   BioSample; SAMN10988392
DR   CCLE; LN235_CENTRAL_NERVOUS_SYSTEM
DR   Cell_Model_Passport; SIDM01367
DR   Cosmic; 849862
DR   Cosmic; 2367491
DR   Cosmic; 2516026
DR   DepMap; ACH-000591
DR   PharmacoDB; LN235_842_2019
DR   Wikidata; Q54902773
RX   PubMed=2990147;
RX   PubMed=7693337;
RX   PubMed=10416987;
RX   PubMed=22570425;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Doubling time: 37 hours (PubMed=25984343).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys176Ser (c.526T>A); ClinVar=VCV000376570; Zygosity=Unspecified (PubMed=10416987).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Genome ancestry: African=3.32%; Native American=0.31%; East Asian, North=4.46%; East Asian, South=0%; South Asian=3.28%; European, North=23.54%; European, South=65.09% (PubMed=30894373).
ST   Source(s): PubMed=22570425
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 9
ST   D16S539: 11
ST   D18S51: 13,16
ST   D21S11: 29,32.2
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 14,15
ST   FGA: 22
ST   Penta D: 11,12
ST   Penta E: 14,15
ST   TH01: 7,9
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   38Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 16
//
RX   PubMed=2990147; DOI=10.1007/BF00688585;
RA   Studer A., de Tribolet N., Diserens A.-C., Gaide A.-C.,
RA   Matthieu J.-M., Carrel S., Stavrou D.;
RT   "Characterization of four human malignant glioma cell lines.";
RL   Acta Neuropathol. 66:208-217(1985).
//
RX   PubMed=7693337;
RA   Li H., Hamou M.-F., de Tribolet N., Jaufeerally R., Hofmann M.,
RA   Diserens A.-C., Van Meir E.G.;
RT   "Variant CD44 adhesion molecules are expressed in human brain
RT   metastases but not in glioblastomas.";
RL   Cancer Res. 53:5345-5349(1993).
//
RX   PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x;
RA   Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C.,
RA   Van Meir E.G.;
RT   "Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor
RT   suppressor genes in human glioma cell lines.";
RL   Brain Pathol. 9:469-479(1999).
//
RX   PubMed=22570425; DOI=10.1093/neuonc/nos072;
RA   Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K.,
RA   Hamou M.-F., Delorenzi M., Hegi M.E.;
RT   "DNA fingerprinting of glioma cell lines and considerations on
RT   similarity measurements.";
RL   Neuro-oncol. 14:701-711(2012).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//