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Cellosaurus LN-319 (CVCL_3958)

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Cell line name LN-319
Synonyms LN 319; LN319
Accession CVCL_3958
Resource Identification Initiative To cite this cell line use: LN-319 (RRID:CVCL_3958)
Comments Problematic cell line: Contaminated. Shown to be a LN-992 derivative (PubMed=22570425).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00450.
Doubling time: 45 hours (PubMed=25984343).
Omics: shRNA library screening.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Arg175His (c.524G>A) (PubMed=7732013; PubMed=10416987).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.71
East Asian, North1.65
East Asian, South0
South Asian1.15
European, North65.6
European, South29.81
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6845 (LN-992)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): PubMed=22570425

Penta D9,13
Penta E15,17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

Li H., Hamou M.-F., de Tribolet N., Jaufeerally R., Hofmann M., Diserens A.-C., Van Meir E.G.
Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.
Cancer Res. 53:5345-5349(1993)

PubMed=7732013; DOI=10.1073/pnas.92.9.3963
Flaman J.-M., Frebourg T., Moreau V., Charbonnier F., Martin C., Chappuis P., Sappino A.-P., Limacher J.-M., Bron L., Benhattar J., Tada M., Van Meir E.G., Estreicher A., Iggo R.D.
A simple p53 functional assay for screening cell lines, blood, and tumors.
Proc. Natl. Acad. Sci. U.S.A. 92:3963-3967(1995)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y., Moncayo G., Hemmings B.A.
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections AddexBio; C0005001/54
Cell line databases/resources CCLE; LN319_CENTRAL_NERVOUS_SYSTEM
Ontologies BTO; BTO:0002215
Biological sample resources BioSample; SAMN03151824
Gene expression databases GEO; GSM397667
GEO; GSM397668
Other Wikidata; Q54902776
Polymorphism and mutation databases Cosmic; 849864
Cosmic; 2367493
Cosmic; 2516027
IARC_TP53; 2572
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number17