ID   CWR22
AC   CVCL_3967
SY   CWR-22; CWR 22
DR   BTO; BTO:0004594
DR   cancercelllines; CVCL_3967
DR   Cosmic; 1689706
DR   NCI-DTP; CWR-22
DR   Wikidata; Q54817054
RX   PubMed=7525052;
RX   PubMed=8433392;
RX   PubMed=8674060;
RX   PubMed=10861745;
RX   PubMed=23671654;
CC   Population: Caucasian.
CC   Microsatellite instability: Instable (MSI) (PubMed=23671654).
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous.
CC   Miscellaneous: This is not a cell line but a xenograft, it is the parent tumor for many cell lines.
CC   Misspelling: CRW22; Note=Occasionally.
CC   Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
//
RX   PubMed=7525052;
RA   Wainstein M.A., He F., Robinson D., Kung H.-J., Schwartz S.,
RA   Giaconia J.M., Edgehouse N.L., Pretlow T.P., Bodner D.R., Kursh E.D.,
RA   Resnick M.I., Seftel A., Pretlow T.G. II;
RT   "CWR22: androgen-dependent xenograft model derived from a primary
RT   human prostatic carcinoma.";
RL   Cancer Res. 54:6049-6052(1994).
//
RX   PubMed=8433392; DOI=10.1093/jnci/85.5.394;
RA   Pretlow T.G. II, Wolman S.R., Micale M.A., Pelley R.J., Kursh E.D.,
RA   Resnick M.I., Bodner D.R., Jacobberger J.W., Delmoro C.M.,
RA   Giaconia J.M., Pretlow T.P.;
RT   "Xenografts of primary human prostatic carcinoma.";
RL   J. Natl. Cancer Inst. 85:394-398(1993).
//
RX   PubMed=8674060;
RA   Nagabhushan M., Miller C.M., Pretlow T.P., Giaconia J.M.,
RA   Edgehouse N.L., Schwartz S., Kung H.-J., deVere White R.W.,
RA   Gumerlock P.H., Resnick M.I., Amini S.B., Pretlow T.G. II;
RT   "CWR22: the first human prostate cancer xenograft with strongly
RT   androgen-dependent and relapsed strains both in vivo and in soft
RT   agar.";
RL   Cancer Res. 56:3042-3046(1996).
//
RX   PubMed=10861745; DOI=10.1002/1097-0045(20000601)43:4<263::AID-PROS5>3.0.CO;2-I;
RA   van Weerden W.M., Romijn J.C.;
RT   "Use of nude mouse xenograft models in prostate cancer research.";
RL   Prostate 43:263-271(2000).
//
RX   PubMed=23671654; DOI=10.1371/journal.pone.0063056;
RA   Lu Y.-H., Soong T.D., Elemento O.;
RT   "A novel approach for characterizing microsatellite instability in
RT   cancer cells.";
RL   PLoS ONE 8:E63056-E63056(2013).
//