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Cellosaurus BON-1 (CVCL_3985)

[Text version]

Cell line name BON-1
Synonyms Bon-1; BON1; BON
Accession CVCL_3985
Secondary accession CVCL_B390
Resource Identification Initiative To cite this cell line use: BON-1 (RRID:CVCL_3985)
Comments Doubling time: 1.5 +- 0.4 days (PubMed=29330294).
Omics: Deep exome analysis.
Disease Serotonin-producing pancreatic neuroendocrine tumor (NCIt: C4446)
Serotonin-producing neuroendocrine tumor of pancreas (ORDO: Orphanet_506090)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=BON

PubMed=1712329; DOI=10.5555/uri:pii:0016508591900045
Evers B.M., Townsend C.M. Jr., Upp J.R. Jr., Allen E., Hurlbut S.C., Kim S.W., Rajaraman S., Singh P., Reubi J.C., Thompson J.C.
Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth.
Gastroenterology 101:303-311(1991)

PubMed=7978888; DOI=10.1111/j.1749-6632.1994.tb17289.x
Evers B.M., Ishizuka J., Townsend C.M. Jr., Thompson J.C.
The human carcinoid cell line, BON. A model system for the study of carcinoid tumors.
Ann. N. Y. Acad. Sci. 733:393-406(1994)

PubMed=8108375; DOI=10.1097/00006676-199401000-00013
Parekh D., Ishizuka J., Townsend C.M. Jr., Haber B., Beauchamp R.D., Karp G., Kim S.W., Rajaraman S., Greeley G. Jr., Thompson J.C.
Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage, and secretion.
Pancreas 9:83-90(1994)

PubMed=19295186; DOI=10.1159/000209330
Siddique Z.-L., Drozdov I., Floch J., Gustafsson B.I., Stunes K., Pfragner R., Kidd M., Modlin I.M.
KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model.
Neuroendocrinology 89:458-470(2009)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=22929519; DOI=10.3791/4218
Wong C., Vosburgh E., Levine A.J., Cong L., Xu E.Y.
Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy.
J. Vis. Exp. 66:e4218-e4218(2012)

PubMed=26087898; DOI=10.1016/j.cancergen.2015.04.002
Boora G.K., Kanwar R., Kulkarni A.A., Pleticha J., Ames M., Schroth G., Beutler A.S., Banck M.S.
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Cancer Genet. 208:374-381(2015)

PubMed=29330294; DOI=10.1158/1541-7786.MCR-17-0163
Benten D., Behrang Y., Unrau L., Weissmann V., Wolters-Eisfeld G., Burdak-Rothkamm S., Stahl F.R., Anlauf M., Grabowski P., Mobs M., Dieckhoff J., Sipos B., Fahl M., Eggers C., Perez D., Bockhorn M., Izbicki J.R., Lohse A.W., Schrader J.
Establishment of the first well-differentiated human pancreatic neuroendocrine tumor model.
Mol. Cancer Res. 16:496-507(2018)

PubMed=29895527; DOI=10.1530/ERC-18-0159
Aristizabal Prada E.T., Spottl G., Maurer J., Lauseker M., Koziolek E.J., Schrader J., Grossman A., Pacak K., Beuschlein F., Auernhammer C.J., Nolting S.
The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance.
Endocr. Relat. Cancer 25:893-908(2018)

Ontologies BTO; BTO:0003856
Other Wikidata; Q54797946
Polymorphism and mutation databases Cosmic; 721017
Cosmic; 1620107
Cosmic; 1879411
Cosmic; 2433550
Cosmic; 2530675
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number11