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Cellosaurus TSU-Pr1 (CVCL_4014)

[Text version]

Cell line name TSU-Pr1
Synonyms Tsu-Pr1; TSU-PR1; TSUpr1; TSU
Accession CVCL_4014
Resource Identification Initiative To cite this cell line use: TSU-Pr1 (RRID:CVCL_4014)
Comments Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=11522622; PubMed=20143388). Originally thought to originate from a 73 year old male patient with a prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00280.
Population: Caucasian; Swedish.
Derived from sampling site: Urinary bladder.
Sequence variations Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
CVCL_M904 (TSU-Pr1-B1)CVCL_M134 (TsuGK27)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx

PubMed=3586177; DOI=10.1016/S0022-5347(17)44488-0
Iizumi T., Yazaki T., Kanoh S., Kondo I., Koiso K.
Establishment of a new prostatic carcinoma cell line (TSU-Pr1).
J. Urol. 137:1304-1306(1987)

Isaacs W.B., Carter B.S., Ewing C.M.
Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.
Cancer Res. 51:4716-4720(1991)

PubMed=9018337; DOI=10.1002/(SICI)1097-0045(19970101)30:1<58::AID-PROS9>3.0.CO;2-H
Webber M.M., Bello D., Quader S.T.A.
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications Part 2. Tumorigenic cell lines.
Prostate 30:58-64(1997)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Rauh-Adelmann C., Lau K.-M., Sabeti N., Long J.P., Mok S.C., Ho S.-M.
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

van Bokhoven A., Varella-Garcia M., Korch C., Miller G.J.
TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin.
Cancer Res. 61:6340-6344(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=16271951; DOI=10.1016/j.cancergencyto.2005.04.010
Kim M.S., Kim S.H., Kim H.J., Hoang I.N., Oh W.M., Koh J.T., Park H.O., Jeong J.Y., Kim W.J., Lee E.J., Koh J.Y., Kim B.Y., Jensen R.H.
Characterization of the TSU-PR1 cell line by chromosome painting and flow cytometry.
Cancer Genet. Cytogenet. 163:17-22(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Ontologies BTO; BTO:0001065
Biological sample resources BioSample; SAMN03151952
Other Wikidata; Q54973170
Polymorphism and mutation databases Cosmic; 704847
Cosmic; 869158
Cosmic; 921049
Cosmic; 922552
Cosmic; 923958
Cosmic; 948073
Cosmic; 1218867
Cosmic; 2444243
IARC_TP53; 753
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number22