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Cellosaurus SK-RC-45 (CVCL_4016)

[Text version]
Cell line name SK-RC-45
Synonyms SK-RC 45; SK RC 45; SKRC-45; SKRC45; RCC 45; RCC45
Accession CVCL_4016
Resource Identification Initiative To cite this cell line use: SK-RC-45 (RRID:CVCL_4016)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Doubling time: 48 hours (PubMed=2386958).
Miscellaneous: STR profile and age/sex of donor from MSKCC antibody and bioresource core facility.
Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4022 ! SK-RC-44
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,23
D3S135815
D5S81812
D7S82012
D8S117912,14
D13S31711,12
D16S53913
D18S5115
D19S43314,16
D21S1127,28
FGA22,23
TH016,8
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-rc-m-metastatic-human-renal-cell-carcinoma-rcc-cell-line-collection
Publications

PubMed=2386958
Ebert T., Bander N.H., Finstad C.L., Ramsawak R.D., Old L.J.
Establishment and characterization of human renal cancer and normal kidney cell lines.
Cancer Res. 50:5531-5536(1990)

PubMed=12670922
Kudo D., Rayman P., Horton C., Cathcart M.K., Bukowski R.M., Thornton M., Tannenbaum C.S., Finke J.H.
Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T cells.
Cancer Res. 63:1676-1683(2003)

PubMed=15026329; DOI=10.1158/0008-5472.CAN-03-1541
Gurova K.V., Hill J.E., Razorenova O.V., Chumakov P.M., Gudkov A.V.
p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.
Cancer Res. 64:1951-1958(2004)

PubMed=27993170; DOI=10.1186/s12943-016-0565-8
Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83.1-83.15(2016)

Cross-references
Anatomy/cell type resources BTO; BTO:0003201
Encyclopedic resources Wikidata; Q54954591
Polymorphism and mutation databases Cosmic; 737189
IARC_TP53; 26509
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number20