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Cellosaurus SCC-12B (CVCL_4027)

[Text version]

Cell line name SCC-12B
Synonyms SCC-12b; SCC 12B; SCC12b; SCC12B; SCC-12 clone B
Accession CVCL_4027
Resource Identification Initiative To cite this cell line use: SCC-12B (RRID:CVCL_4027)
Sequence variations HRAS p.Gly12Leu (from parent cell line).
TP53 p.Val216Gly (c.647T>G) (ClinVar=VCV000376671) (PubMed=8390283).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4026 (SCC-12)
CVCL_M672 (SCC-12B.2)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line

PubMed=1574572; DOI=10.2307/3578273
Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8390283; DOI=10.1038/bjc.1993.238
Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G., Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=22006338; DOI=10.1073/pnas.1114669108
Wang N.J., Sanborn Z., Arnett K.L., Bayston L.J., Liao W., Proby C.M., Leigh I.M., Collisson E.A., Gordon P.B., Jakkula L.R., Pennypacker S., Zou Y., Sharma M., North J.P., Vemula S.S., Mauro T.M., Neuhaus I.M., LeBoit P.E., Hur J.S., Park K., Huh N., Kwok P.-Y., Arron S.T., Massion P.P., Bale A.E., Haussler D., Cleaver J.E., Gray J.W., Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011)

Ontologies BTO; BTO:0002192
Other Wikidata; Q54952328
Polymorphism and mutation databases Cosmic; 1608862
IARC_TP53; 1910
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number10