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Cellosaurus FA6 (CVCL_4034)

[Text version]
Cell line name FA6
Synonyms FA-6
Accession CVCL_4034
Resource Identification Initiative To cite this cell line use: FA6 (RRID:CVCL_4034)
Comments Derived from site: Metastatic; Supraclavicular lymph node; UBERON=UBERON_0035279.
Sequence variations
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (PubMed=11787853).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser149fs (c.445del840); Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
Disease Pancreatic adenocarcinoma (NCIt: C8294)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 49Y
Category Cancer cell line
Web pages https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/FA6.html
Publications

PubMed=2543550; DOI=10.1507/endocrj1954.36.75
Nagata N., Akatsu T., Kugai N., Yasutomo Y., Kinoshita T., Kosano H., Shimauchi T., Takatani O., Ueyama Y.
The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity.
Endocrinol. Jpn. 36:75-85(1989)

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C
Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M., Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Int. J. Cancer 91:350-358(2001)

PubMed=11787853; DOI=10.1007/s004280100474
Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R., Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H., Lohr J.-M., Scarpa A.
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Virchows Arch. 439:798-802(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4034
Encyclopedic resources Wikidata; Q54833212
Experimental variables resources EFO; EFO_0006392
Polymorphism and mutation databases Cosmic; 710855
IARC_TP53; 16738
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22