Cellosaurus HuH-6 (CVCL_4381)

Cell line name HuH-6
Synonyms HUH-6; HuH 6; HuH6; HUH6; Huh6
Accession CVCL_4381
Resource Identification Initiative To cite this cell line use: HuH-6 (RRID:CVCL_4381)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: JFCR45 cancer cell line panel.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Hepatoblastoma (NCIt: C3728)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_1296 (HuH-6 Clone 5); CVCL_JF84 (HuH-6-Luc); CVCL_M176 (HUH6-eGFP)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S3178,12
D16S53910,11
D5S8188,11
D7S82011,12
TH017,8
TPOX8
vWA14,17
Publications

PubMed=57894
Doi I.
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.
Gann 67:1-10(1976)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C.
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=23887712; DOI=10.1038/ncomms3218
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218-2218(2013)

Cross-references
Cell line collections RCB; RCB1367
Cell line databases/resources CCLE; HUH6_LIVER
Ontologies BTO; BTO:0001670
CLO; CLO_0050851
Gene expression databases GEO; GSM887148
GEO; GSM888220
GEO; GSM936762
Polymorphism and mutation databases Cosmic; 869168
Cosmic; 869279
Cosmic; 873714
Cosmic; 1187329
Cosmic; 1237546
Cosmic; 1518228
Cosmic; 1622750
Cosmic; 2162537
Cosmic; 2369478