Home  |  Contact

Cellosaurus HuH-6 (CVCL_4381)

[Text version]

Cell line name HuH-6
Synonyms HUH-6; HuH 6; HuH6; HUH6; Huh6
Accession CVCL_4381
Resource Identification Initiative To cite this cell line use: HuH-6 (RRID:CVCL_4381)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: JFCR45 cancer cell line panel.
Population: Japanese.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for CTNNB1 p.Gly34Val (c.101G>T) (ClinVar=VCV000017582) (PubMed=9671767).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.79
Native American0.3
East Asian, North80.92
East Asian, South17.99
South Asian0
European, North0
European, South0
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1296 (HuH-6 Clone 5)CVCL_JF84 (HuH-6-Luc)CVCL_M176 (HUH6-eGFP)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): CCRID; RCB

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818
D3S135814,17
D5S8188,11
D7S82011,12
D8S117910,11
D13S3178,12
D16S53910,11
D18S5113,21
D19S43312,12.2
D21S1129,30
FGA19,24
TH017,8
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=1691
Publications

PubMed=57894
Doi I.
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.
Gann 67:1-10(1976)

DOI=10.11418/jtca1981.12.3_221
Namba M., Nakabayashi H., Doi I., Sato J., Miyazaki M.
Cellular characteristics and utilization of human hepatoma cell lines which were established in our laboratory and distributed by Japanese Cancer Research Resources Bank.
Tissue Cult. Res. Commun. 12:221-227(1993)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C.
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

DOI=10.11418/jtca1981.16.3_173
Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

PubMed=9671767; DOI=10.1073/pnas.95.15.8847
de La Coste A., Romagnolo B., Billuart P., Renard C.-A., Buendia M.-A., Soubrane O., Fabre M., Chelly J., Beldjord C., Kahn A., Perret C.
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 95:8847-8851(1998)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=20937217; DOI=10.1170/149
Di Masi A., Viganotti M., Antoccia A., Magrelli A., Salvatore M., Azzalin G., Tosto F., Lorenzetti S., Maranghi F., Mantovani A., Macino G., Tanzarella C., Taruscio D.
Characterization of HuH6, Hep3B, HepG2 and HLE liver cancer cell lines by WNT/beta - catenin pathway, microRNA expression and protein expression profile.
Cell. Mol. Biol. 56:OL1299-OL1317(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=23887712; DOI=10.1038/ncomms3218
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218-2218(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections RCB; RCB1367
Cell line databases/resources CCLE; HUH6_LIVER
CCRID; 3131C0001000700180
Cell_Model_Passport; SIDM00062
DepMap; ACH-000671
Ontologies BTO; BTO:0001670
CLO; CLO_0050851
Biological sample resources BioSample; SAMN10987713
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887148
GEO; GSM888220
GEO; GSM936762
Other Wikidata; Q54896848
Polymorphism and mutation databases Cosmic; 869168
Cosmic; 869279
Cosmic; 873714
Cosmic; 1187329
Cosmic; 1237546
Cosmic; 1518228
Cosmic; 1622750
Cosmic; 2162537
Cosmic; 2369478
LiGeA; CCLE_149
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number25