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Cellosaurus TMK-1 (CVCL_4384)

[Text version]

Cell line name TMK-1
Synonyms TMK1
Accession CVCL_4384
Resource Identification Initiative To cite this cell line use: TMK-1 (RRID:CVCL_4384)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Val173Met (c.517G>A) (PubMed=1370612; PubMed=1933850).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.05
Native American0.49
East Asian, North70.76
East Asian, South27.97
South Asian0
European, North0.73
European, South0
Disease Gastric adenocarcinoma (NCIt: C4004)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_F953 ! SC-6-JCK
Sex of cell Male
Age at sampling 21Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO10,12
D5S81810,13
D7S8208,12
D13S31710,13
D16S5399
TH019
TPOX8,10
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=1933850
Yamada Y., Yoshida T., Hayashi K., Sekiya T., Yokota J., Hirohashi S., Nakatani K., Nakano H., Sugimura T., Terada M.
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Cancer Res. 51:5800-5805(1991)

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochem. Biophys. Res. Commun. 182:215-223(1992)

DOI=10.1016/B978-0-12-333530-2.50014-9
Sekiguchi M., Suzuki T.
Gastric tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)

PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x
Yokozaki H.
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Pathol. Int. 50:767-777(2000)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; TMK1_STOMACH
Cell_Model_Passport; SIDM00040
Cosmic-CLP; 1299069
DepMap; ACH-002202
GDSC; 1299069
TOKU-E; 4022
Ontologies BTO; BTO:0003219
EFO; EFO_0002867
Gene expression databases GEO; GSM552377
GEO; GSM562397
Other Wikidata; Q54972697
Polymorphism and mutation databases Cosmic; 887251
Cosmic; 888829
Cosmic; 897537
Cosmic; 922689
Cosmic; 926110
Cosmic; 1122341
Cosmic; 1187298
Cosmic; 1223585
Cosmic; 1460701
Cosmic; 1482078
Cosmic; 1518245
Cosmic; 1571762
IARC_TP53; 974
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number18