ID   NR8383
AC   CVCL_4396
SY   NR-8383; NR 8383; NR8383.1; NR8383 clone AgCl1X3A; AgC11x3A; Normal Rat, August 3, 1983
DR   BTO; BTO:0002907
DR   CLO; CLO_0008193
DR   ATCC; CRL-2192
DR   BCRC; 60423
DR   CCRID; 1101RAT-PUMC000663
DR   CCRID; 3101RATGNR9
DR   CLS; 305200
DR   KCB; KCB 2010189YJ
DR   Lonza; 1390
DR   Wikidata; Q54931021
RX   PubMed=2914814;
RX   PubMed=3497918;
RX   PubMed=9738661;
RX   PubMed=28242876;
WW   https://www.atcc.org/en/support/technical-support/faqs/morphology-of-crl-2192
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Provides a homogenous source of highly responsive alveolar macrophages which can be used in vitro to study macrophage related activities (ATCC=CRL-2192).
CC   Anecdotal: Have been flown in space on the ISS in 2014-2015 to study growth and adaptation to microgravity (PubMed=28242876).
CC   Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
CC   Cell type: Alveolar macrophage; CL=CL_0000583.
CC   Breed/subspecies: Sprague Dawley.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 22
//
RX   PubMed=2914814; DOI=10.1007/BF02624409;
RA   Helmke R.J., German V.F., Mangos J.A.;
RT   "A continuous alveolar macrophage cell line: comparisons with freshly
RT   derived alveolar macrophages.";
RL   In Vitro Cell. Dev. Biol. 25:44-48(1989).
//
RX   PubMed=3497918; DOI=10.1007/BF02620974;
RA   Helmke R.J., Boyd R.L., German V.F., Mangos J.A.;
RT   "From growth factor dependence to growth factor responsiveness: the
RT   genesis of an alveolar macrophage cell line.";
RL   In Vitro Cell. Dev. Biol. 23:567-574(1987).
//
RX   PubMed=9738661; DOI=10.1002/jlb.64.3.345;
RA   Lane K.B., Egan B., Vick S., Abdolrasulnia R., Shepherd V.L.;
RT   "Characterization of a rat alveolar macrophage cell line that
RT   expresses a functional mannose receptor.";
RL   J. Leukoc. Biol. 64:345-350(1998).
//
RX   PubMed=28242876; DOI=10.1038/s41598-017-00119-6;
RA   Thiel C.S., de Zelicourt D., Tauber S., Adrian A., Franz M.,
RA   Simmet D.M., Schoppmann K., Hauschild S., Krammer S., Christen M.,
RA   Bradacs G., Paulsen K., Wolf S.A., Braun M., Hatton J.P., Kurtcuoglu V.,
RA   Franke S., Tanner S., Cristoforetti S., Sick B., Hock B., Ullrich O.;
RT   "Rapid adaptation to microgravity in mammalian macrophage cells.";
RL   Sci. Rep. 7:43-43(2017).
//