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Cellosaurus RERF-LC-A1 (CVCL_4402)

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Cell line name RERF-LC-A1
Synonyms RERF-LC-AI; RERFLCAI; Radiation Effects Research Foundation-Lung Cancer-AI
Accession CVCL_4402
Resource Identification Initiative To cite this cell line use: RERF-LC-A1 (RRID:CVCL_4402)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: PERF-LC-AI; In PubMed=12794755.
Sequence variations EGFR p.Leu858Arg (c.2573T>G) (PubMed=16105816).
Homozygous for TP53 p.Gln104Ter (c.310C>T) (PubMed=12794755; CCLE).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*24:02
HLA-BB*52:01
HLA-CC*12:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.35
Native American0
East Asian, North91.19
East Asian, South6.87
South Asian0.45
European, North1.14
European, South0
Disease Squamous cell lung carcinoma (NCIt: C3493)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1237 (GT3TKB)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=11416159; RCB

Markers:
AmelogeninX
CSF1PO10
D5S81811
D7S8208,12
D8S117912,14
D13S31712
D16S53910
D18S5121
D21S1129,32.2
FGA25
TH017
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=21559605; DOI=10.3892/ijo.5.3.501
Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.
Scid mice model for the in-vivo study of human oncotherapy - studies on the growth and metastasis of human lung-cancer.
Int. J. Oncol. 5:501-508(1994)

PubMed=7790314; DOI=10.1111/j.1349-7006.1995.tb03073.x
Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.
A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue.
Jpn. J. Cancer Res. 86:419-423(1995)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=12794755; DOI=10.1002/ijc.11184
Endoh H., Yatabe Y., Shimizu S., Tajima K., Kuwano H., Takahashi T., Mitsudomi T.
RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.
Int. J. Cancer 106:45-51(2003)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x
Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y., Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K., Yasumoto K.
Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.
Cancer Sci. 98:1048-1054(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22576795; DOI=10.3892/or.2012.1763
Ashinuma H., Takiguchi Y., Kitazono S., Kitazono-Saitoh M., Kitamura A., Chiba T., Tada Y., Kurosu K., Sakaida E., Sekine I., Tanabe N., Iwama A., Yokosuka O., Tatsumi K.
Antiproliferative action of metformin in human lung cancer cell lines.
Oncol. Rep. 28:8-14(2012)

PubMed=24002593; DOI=10.1038/bjc.2013.452
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB0444
Cell line databases/resources CCLE; RERFLCAI_LUNG
Cell_Model_Passport; SIDM00307
DepMap; ACH-000261
Ontologies CLO; CLO_0050027
EFO; EFO_0002850
Biological sample resources BioSample; SAMN03472317
BioSample; SAMN10987780
Chemistry resources ChEMBL-Cells; CHEMBL3307414
ChEMBL-Targets; CHEMBL614633
PharmacoDB; RERFLCAI_1303_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887534
GEO; GSM888616
Other Wikidata; Q54949758
Polymorphism and mutation databases Cosmic; 934471
Cosmic; 946074
Cosmic; 1048225
Cosmic; 1089229
Cosmic; 1571723
Cosmic; 2060524
Cosmic; 2645025
IARC_TP53; 18791
LiGeA; CCLE_053
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number19