ID   RERF-LC-A1
AC   CVCL_4402
SY   RERF-LC-AI; RERF-LCAI; RERFLCAI; AOI; Radiation Effects Research Foundation-Lung Cancer-AI
DR   BTO; BTO:0006227
DR   CLO; CLO_0050027
DR   EFO; EFO_0002850
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 481
DR   BioSample; SAMN03472317
DR   BioSample; SAMN10987780
DR   cancercelllines; CVCL_4402
DR   Cell_Model_Passport; SIDM00307
DR   ChEMBL-Cells; CHEMBL3307414
DR   ChEMBL-Targets; CHEMBL614633
DR   Cosmic; 934471
DR   Cosmic; 946074
DR   Cosmic; 1048225
DR   Cosmic; 1089229
DR   Cosmic; 1571723
DR   Cosmic; 2060524
DR   Cosmic; 2645025
DR   DepMap; ACH-000261
DR   GEO; GSM887534
DR   GEO; GSM888616
DR   IARC_TP53; 18791
DR   IARC_TP53; 21634
DR   IARC_TP53; 30152
DR   LiGeA; CCLE_053
DR   PharmacoDB; RERFLCAI_1303_2019
DR   Progenetix; CVCL_4402
DR   PubChem_Cell_line; CVCL_4402
DR   RCB; RCB0444
DR   Wikidata; Q54949758
RX   PubMed=7790314;
RX   PubMed=7834619;
RX   PubMed=9023415;
RX   PubMed=9538136;
RX   PubMed=11416159;
RX   PubMed=12794755;
RX   PubMed=15901131;
RX   PubMed=16105816;
RX   PubMed=17511773;
RX   PubMed=21559605;
RX   PubMed=22460905;
RX   PubMed=22576795;
RX   PubMed=24002593;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   HLA typing: A*24:02; B*52:01; C*12:02 (PubMed=9023415).
CC   HLA typing: A*24:02,24:02; B*35:06,52:01; C*12:02,12:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (PubMed=16105816).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln104Ter (c.310C>T); ClinVar=VCV000566924; Zygosity=Homozygous (PubMed=12794755; PubMed=15901131; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.35%; Native American=0%; East Asian, North=91.19%; East Asian, South=6.87%; South Asian=0.45%; European, North=1.14%; European, South=0% (PubMed=30894373).
CC   Misspelling: PERF-LC-AI; PubMed=12794755.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=11416159; RCB
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 10
ST   D18S51: 21
ST   D21S11: 29,32.2
ST   D5S818: 11
ST   D7S820: 8,12
ST   D8S1179: 12,14
ST   FGA: 25
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 29
//
RX   PubMed=7790314; DOI=10.1111/j.1349-7006.1995.tb03073.x;
RA   Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.;
RT   "A novel SCID mouse model for studying spontaneous metastasis of human
RT   lung cancer to human tissue.";
RL   Jpn. J. Cancer Res. 86:419-423(1995).
//
RX   PubMed=7834619;
RA   Washimi O., Nagatake M., Osada H., Ueda R., Koshikawa T., Seki T.,
RA   Takahashi T., Takahashi T.;
RT   "In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations
RT   preferentially in non-small cell lung cancers.";
RL   Cancer Res. 55:514-517(1995).
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.;
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=9538136; DOI=10.3892/ijo.12.5.1103;
RA   Takaki T., Hiraki A., Uenaka A., Gomi S., Itoh K., Udono H.,
RA   Shibuya A., Tsuji T., Sekiguchi S., Nakayama E.;
RT   "Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-
RT   3 peptide recognized by cytotoxic T lymphocytes.";
RL   Int. J. Oncol. 12:1103-1109(1998).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=12794755; DOI=10.1002/ijc.11184;
RA   Endoh H., Yatabe Y., Shimizu S., Tajima K., Kuwano H., Takahashi T.,
RA   Mitsudomi T.;
RT   "RASSF1A gene inactivation in non-small cell lung cancer and its
RT   clinical implication.";
RL   Int. J. Cancer 106:45-51(2003).
//
RX   PubMed=15901131; DOI=10.1016/j.prp.2005.01.002;
RA   Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.;
RT   "Correlation between DNA alterations and p53 and p16 protein
RT   expression in cancer cell lines.";
RL   Pathol. Res. Pract. 201:109-115(2005).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M.,
RA   Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.;
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x;
RA   Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y.,
RA   Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K.,
RA   Yasumoto K.;
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=21559605; DOI=10.3892/ijo.5.3.501;
RA   Teraoka S., Kyoizumi S., Seyama T., Yamakido M., Akiyama M.;
RT   "Scid mice model for the in-vivo study of human oncotherapy -- studies
RT   on the growth and metastasis of human lung-cancer.";
RL   Int. J. Oncol. 5:501-508(1994).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22576795; DOI=10.3892/or.2012.1763;
RA   Ashinuma H., Takiguchi Y., Kitazono S., Kitazono-Saitoh M.,
RA   Kitamura A., Chiba T., Tada Y., Kurosu K., Sakaida E., Sekine I.,
RA   Tanabe N., Iwama A., Yokosuka O., Tatsumi K.;
RT   "Antiproliferative action of metformin in human lung cancer cell
RT   lines.";
RL   Oncol. Rep. 28:8-14(2012).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452;
RA   Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.;
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//