Cellosaurus cell line LIM1899 (CVCL_4435)

• Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Unspecified (PubMed=24755471).
  
• Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (PubMed=12068308; PubMed=19378335; PubMed=24755471).
  

PubMed=2386931
Andrew S.M., Teh J.G., Johnstone R.W., Russell S.M., Whitehead R.H., McKenzie I.F.C., Pietersz G.A.
Tumor localization by combinations of monoclonal antibodies in a new human colon carcinoma cell line (LIM1899).
Cancer Res. 50:5225-5230(1990)

PubMed=1427983; DOI=10.1038/icb.1992.30
Whitehead R.H., Zhang H.H., Hayward I.P.
Retention of tissue-specific phenotype in a panel of colon carcinoma cell lines: relationship to clinical correlates.
Immunol. Cell Biol. 70:227-236(1992)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=19378335; DOI=10.1002/ijc.24289
Zhang H.-H., Walker F., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=23458625; DOI=10.1021/pr3010869
Fanayan S., Smith J.T., Lee L.Y., Yan F.-F., Snyder M.P., Hancock W.S., Nice E.
Proteogenomic analysis of human colon carcinoma cell lines LIM1215, LIM1899, and LIM2405.
J. Proteome Res. 12:1732-1742(2013)

PubMed=24295106; DOI=10.1021/pr400861m
Sethi M.K., Thaysen-Andersen M., Smith J.T., Baker M.S., Packer N.H., Hancock W.S., Fanayan S.
Comparative N-glycan profiling of colorectal cancer cell lines reveals unique bisecting GlcNAc and alpha-2,3-linked sialic acid determinants are associated with membrane proteins of the more metastatic/aggressive cell lines.
J. Proteome Res. 13:277-288(2014)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)