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Cellosaurus LIM2551 (CVCL_4443)

[Text version]
Cell line name LIM2551
Synonyms LIM 2551; LIM-2551
Accession CVCL_4443
Resource Identification Initiative To cite this cell line use: LIM2551 (RRID:CVCL_4443)
Comments From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Microsatellite instability: Instable (MSI) (PubMed=19378335; PubMed=24755471; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: Sex of donor from original lab book of Whitehead R.H. and from patient surgeon through a personal communication of Cape-Davis A.
Derived from site: In situ; Colon, transverse; UBERON=UBERON_0001157.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=19378335; PubMed=24755471).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Thr578Pro (c.1732A>C); Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=24755471).
  • Mutation; HGNC; 6769; SMAD3; Simple; p.Ala202Thr (c.604G>A); ClinVar=VCV001171415; Zygosity=Unspecified (PubMed=24755471).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): CBA; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133817,23
D3S135816,17
D5S81812,16
D7S8209,11
D8S117912,13
D13S3178,10
D16S53911
D18S5115,16
D19S43312
D21S1128,33.2
FGA22,23,24
TH016,9.3
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=19378335; DOI=10.1002/ijc.24289
Zhang H.-H., Walker F., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line collections (Providers) CBA; CBA-0170
ECACC; 12070505
Cell line databases/resources cancercelllines; CVCL_4443
ColonAtlas; LIM2551
Biological sample resources BioSample; SAMN07624418
Encyclopedic resources Wikidata; Q54902541
Gene expression databases GEO; GSM1346881
GEO; GSM1448076
GEO; GSM3145718
Polymorphism and mutation databases Cosmic; 1238059
Cosmic; 1486141
Cosmic; 1803947
Cosmic; 2301995
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number28