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Cellosaurus UW228-1 (CVCL_4460)

[Text version]
Cell line name UW228-1
Accession CVCL_4460
Resource Identification Initiative To cite this cell line use: UW228-1 (RRID:CVCL_4460)
Comments Doubling time: 25.2 +- 2.1 hours (PubMed=8866661).
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (from parent cell line).
Disease Medulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8585 (UW228)
Sex of cell Female
Age at sampling 9Y
Category Cancer cell line
Publications

PubMed=1292757
Keles G.E., Berger M.S., Lim R., Zaheer A., Denton A.L., Silber J.R.
Expression of glial fibrillary acidic protein in human medulloblastoma cells treated with recombinant glia maturation factor-beta.
Oncol. Res. 4:431-437(1992)

PubMed=8866661
Keles G.E., Berger M.S., Srinivasan J., Kolstoe D.D., Bobola M.S., Silber J.R.
Establishment and characterization of four human medulloblastoma-derived cell lines.
Oncol. Res. 7:493-503(1995)

PubMed=8674085; DOI=10.1007/BF00819500
Srinivasan J., Berger M.S., Silber J.R.
p53 expression in four human medulloblastoma-derived cell lines.
Childs Nerv. Syst. 12:76-80(1996)

PubMed=15814657; DOI=10.1158/1078-0432.CCR-04-2045
Bobola M.S., Silber J.R., Ellenbogen R.G., Geyer J.R., Blank A., Goff R.D.
O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
Clin. Cancer Res. 11:2747-2755(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4460
Anatomy/cell type resources BTO; BTO:0004330
Encyclopedic resources Wikidata; Q54992373
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21