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Cellosaurus JHUEM-3 (CVCL_4657)

[Text version]

Cell line name JHUEM-3
Synonyms JHUEM3
Accession CVCL_4657
Resource Identification Initiative To cite this cell line use: JHUEM-3 (RRID:CVCL_4657)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: TCGA-110-CL cell line panel.
Population: Japanese.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Uterus.
Sequence variations Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Heterozygous (CCLE).
Mutation; HGNC; 6407; KRAS; Simple; p.Asp33Glu (c.99T>A); Zygosity=Heterozygous (CCLE).
Mutation; HGNC; 11998; TP53; Simple; p.Gln167Ter (c.499C>T); ClinVar=VCV000528250; Zygosity=Unspecified (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.23
Native American0
East Asian, North84.53
East Asian, South12.99
South Asian0
European, North0
European, South2.25
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX
CSF1PO11,12
D5S81811
D7S8209,11
D13S3178,13
D16S5399,11
TH017
TPOX8,11
vWA14,19,20

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cross-references
Cell line collections RCB; RCB1552
Cell line databases/resources CCLE; JHUEM3_ENDOMETRIUM
DepMap; ACH-000173
Ontologies CLO; CLO_0050875
Biological sample resources BioSample; SAMN03472102
BioSample; SAMN10987748
Chemistry resources PharmacoDB; JHUEM3_700_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887182
GEO; GSM888254
Other Wikidata; Q54898915
Polymorphism and mutation databases Cosmic; 2030476
IARC_TP53; 30086
LiGeA; CCLE_816
Progenetix; CVCL_4657
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number20