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Cellosaurus 184B5 (CVCL_4688)

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Cell line name 184B5
Synonyms 184-B5; B5/589; H184B5
Accession CVCL_4688
Secondary accession CVCL_B387; CVCL_Y092
Resource Identification Initiative To cite this cell line use: 184B5 (RRID:CVCL_4688)
Comments Part of: ICBP43 breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Transformant: ChEBI; CHEBI:29865; Benzo[a]pyrene.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*50:01,18:01
HLA-CC*07:01,06:02
Class II
HLA-DQDQB1*06:04,06:04
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_K049 (184)
Children:
CVCL_IQ00 (B5KTu)CVCL_IP80 (H184B5-F5)
Sex of cell Female
Age at sampling 21Y
Category Transformed cell line
STR profile Source(s): ATCC; PubMed=28889351

Markers:
AmelogeninX
CSF1PO10
D5S81811
D7S8209,11
D13S31711
D16S53911,12
D21S1129,30
TH019.3
TPOX11
vWA18,19

Run an STR similarity search on this cell line
Web pages http://hmec.lbl.gov/mreview.htm
http://lincs.hms.harvard.edu/resources/reagents/icbp43/
http://tcpaportal.org/mclp/
Publications

PubMed=3857588; DOI=10.1073/pnas.82.8.2394
Stampfer M.R., Bartley J.C.
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
Proc. Natl. Acad. Sci. U.S.A. 82:2394-2398(1985)

Patent=US4808532
Stampfer M.R.
Continuous human cell lines and method of making same.
Patent number US4808532, 28-Feb-1989

PubMed=2702624; DOI=10.1016/0165-4608(89)90056-3
Walen K.H., Stampfer M.R.
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality.
Cancer Genet. Cytogenet. 37:249-261(1989)

DOI=10.1007/978-1-4612-0411-4_10
Yang T.C., Stampfer M.R., Rhim J.S.
Neoplastic transformation of human epithelial cells by ionizing radiation.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.103-111; Humana Press; New York (1990)

DOI=10.1007/978-1-4612-0411-4_26
Stampfer M.R., Yaswen P., Parry G., Hosoda J.
An in vitro human mammary epithelial model system for studies of differentiation and carcinogenesis.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.259-267; Humana Press; New York (1990)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

PubMed=9303071; DOI=10.1002/(SICI)1520-6823(1997)5:3<134::AID-ROI10>3.0.CO;2-6
Yang T.C.-H., Georgy K.A., Craise L.M., Durante M.
Initiation of oncogenic transformation in human mammary epithelial cells by charged particles.
Radiat. Oncol. Investig. 5:134-138(1997)

PubMed=9671407; DOI=10.1038/sj.onc.1201814
Sweeney K.J., Swarbrick A., Sutherland R.L., Musgrove E.A.
Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells.
Oncogene 16:2865-2878(1998)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Saunus J.M., Smart C.E., Kutasovic J.R., Johnston R.L., Kalita-de Croft P., Miranda M., Rozali E.N., Vargas A.C., Reid L.E., Lorsy E., Cocciardi S., Seidens T., McCart Reed A.E., Dalley A.J., Wockner L.F., Johnson J., Sarkar D., Askarian-Amiri M.E., Simpson P.T., Khanna K.K., Chenevix-Trench G., Al-Ejeh F., Lakhani S.R.
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

Cross-references
Cell line collections ATCC; CRL-8799
IZSLER; BS CL 170
Cell line databases/resources LINCS_HMS; 50576
LINCS_LDP; LCL-2081
Ontologies BTO; BTO:0002180
CLO; CLO_0001138
Biological sample resources BioSample; SAMN03471211
Gene expression databases GEO; GSM1172933
GEO; GSM1172845
Other Wikidata; Q54582483
Entry history
Entry creation04-Apr-2012
Last entry updated25-Feb-2019
Version number21