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Cellosaurus PK-1 (CVCL_4717)

[Text version]

Cell line name PK-1
Synonyms PK1
Accession CVCL_4717
Resource Identification Initiative To cite this cell line use: PK-1 (RRID:CVCL_4717)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Japanese.
Doubling time: 48 hours (PubMed=3547771; PubMed=6205469); 24.1 hours (PubMed=8872523).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=11115575; PubMed=22490663; CCLE).
Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=11115575; PubMed=22490663; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.26
Native American0
East Asian, North88.21
East Asian, South8.65
South Asian0.93
European, North0.7
European, South1.25
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5146 (KLM-1)CVCL_0B31 (RPK-1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815
D5S81811,12
D7S82011
D8S117910,15
D13S3179,10
D16S53912
D18S5113
D21S1131
FGA22,24
Penta D9
Penta E9,20
TH019 (TKG)
9,10 (PubMed=25877200; RCB)
TPOX9,11
vWA15,19

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Publications

PubMed=6205469; DOI=10.1620/tjem.143.33
Kobari M., Matsuno S., Sato T., Kan M., Tachibana T.
Establishment of a human pancreatic cancer cell line and detection of pancreatic cancer associated antigen.
Tohoku J. Exp. Med. 143:33-46(1984)

PubMed=3547771; DOI=10.1620/tjem.150.231
Kobari M., Hisano H., Matsuno S., Sato T., Kan M., Tachibana T.
Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.
Tohoku J. Exp. Med. 150:231-248(1986)

PubMed=8872523; DOI=10.1007/BF02787375
Kimura Y., Kobari M., Yusa T., Sunamura M., Kimura M., Shimamura H., Matsuno S.
Establishment of an experimental liver metastasis model by intraportal injection of a newly derived human pancreatic cancer cell line (KLM-1).
Int. J. Pancreatol. 20:43-50(1996)

PubMed=11115575; DOI=10.3892/or.8.1.89
Sun C., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R.L., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB1972
TKG; TKG 0239
Cell line databases/resources CCLE; PK1_PANCREAS
Cell_Model_Passport; SIDM01321
DepMap; ACH-000307
Ontologies BTO; BTO:0004854
CLO; CLO_0050105
Biological sample resources BioSample; SAMN03472897
BioSample; SAMN10988147
Chemistry resources PharmacoDB; PK1_1265_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM862564
GEO; GSM862566
GEO; GSM887515
GEO; GSM888597
GEO; GSM1588614
GEO; GSM1588626
Other Wikidata; Q54947429
Polymorphism and mutation databases Cosmic; 707253
Cosmic; 1066176
Cosmic; 1644297
Cosmic; 2046536
IARC_TP53; 14301
LiGeA; CCLE_500
Progenetix; CVCL_4717
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number24