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Cellosaurus ALVA-41 (CVCL_4734)

[Text version]
Cell line name ALVA-41
Synonyms ALVA 41; ALVA41; American Lake VA-41
Accession CVCL_4734
Resource Identification Initiative To cite this cell line use: ALVA-41 (RRID:CVCL_4734)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from the bone metastasis in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00174.
Population: Caucasian.
Doubling time: 22-24 hours (PubMed=7533340); 20 hours (PubMed=8561862).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (PubMed=11304728).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): PubMed=11304728

Markers:
AmelogeninX
D3S135816,17
D5S81813,14
D7S8208,11
D8S117913
D13S31711
D18S5114,15
D21S1129,31.2
FGA24
vWA17

Run an STR similarity search on this cell line
Web pages https://web.archive.org/web/20160703200531/http://capcelllines.ca:80/details.asp?id=84
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=1958578; DOI=10.1016/0960-0760(91)90309-S
Plymate S.R., Loop S.M., Hoop R.C., Wiren K.M., Ostenson R.C., Hryb D.J., Rosner W.
Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma.
J. Steroid Biochem. Mol. Biol. 40:833-839(1991)

PubMed=7533340; DOI=10.1016/0039-128X(94)90052-3
Nakhla A.M., Rosner W.
Characterization of ALVA-41 cells, a new human prostatic cancer cell line.
Steroids 59:586-589(1994)

PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O
Mehta P.P., Lokeshwar B.L., Schiller P.C., Bendix M.V., Ostenson R.C., Howard G.A., Roos B.A.
Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.
Mol. Carcinog. 15:18-32(1996)

PubMed=11304728; DOI=10.1002/pros.1045
van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

CLPUB00698
van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=15643172; DOI=10.1097/01.ju.0000141580.30910.57
Sobel R.E., Sadar M.D.
Cell lines used in prostate cancer research: a compendium of old and new lines -- part 1.
J. Urol. 173:342-359(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4734
Anatomy/cell type resources BTO; BTO:0002006
Biological sample resources BioSample; SAMN03151890
Encyclopedic resources Wikidata; Q54749378
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25