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Cellosaurus LAPC-4 (CVCL_4744)

Cell line name LAPC-4
Synonyms LAPC4; Los Angeles Prostate Cancer-4
Accession CVCL_4744
Resource Identification Initiative To cite this cell line use: LAPC-4 (RRID:CVCL_4744)
Comments Characteristics: Has lost chromosome Y.
Doubling time: ~72 hours.
Omics: Array-based CGH.
Omics: Deep RNAseq analysis.
Omics: Transcriptome analysis.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,02:01
HLA-BB*14:06,46:01
HLA-CC*05:01,05:01
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RA56 (LAPC-4-EnzR)CVCL_4745 (LAPC-4*2)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO12,13
D13S3179,10,11,12 (ATCC)
10,12 (PubMed=14518029)
D16S5399
D18S5114,15,22
D21S1128,30
D3S135815,17
D5S81812 (ATCC)
11,13 (PubMed=14518029)
D7S82010,10.3,11 (ATCC)
11 (PubMed=14518029)
D8S117913
FGA21,22
TH016,9.3
TPOX8
vWA15,16 (ATCC)
16 (PubMed=14518029)
Web pages https://en.wikipedia.org/wiki/LAPC4
Publications

PubMed=9095173; DOI=10.1038/nm0497-402
Klein K.A., Reiter R.E., Redula J., Moradi H., Zhu X.L., Brothman A.R., Lamb D.J., Marcelli M., Belldegrun A.S., Witte O.N., Sawyers C.L.
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.
Nat. Med. 3:402-408(1997)

PubMed=10861745; DOI=10.1002/1097-0045(20000601)43:4<263::AID-PROS5>3.0.CO;2-I
van Weerden W.M., Romijn J.C.
Use of nude mouse xenograft models in prostate cancer research.
Prostate 43:263-271(2000)

Patent=US6365797
Sawyers C.L., Klein K.A., Witte O.N., Reiter R.E.
Mice models of human prostate cancer progression.
Patent number US6365797, 02-Apr-2002

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=15486987; DOI=10.1002/pros.20158
Zhao H., Kim Y., Wang P., Lapointe J., Tibshirani R., Pollack J.R., Brooks J.D.
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

Cross-references
Cell line collections ATCC; CRL-13009 - Discontinued
ATCC; PTA-1441 - Discontinued
Ontologies BTO; BTO:0002997
EFO; EFO_0005392
Biological sample resources BioSample; SAMN03471350
Chemistry resources ChEMBL-Cells; CHEMBL3308023
ChEMBL-Targets; CHEMBL613292
Gene expression databases GEO; GSM91931
GEO; GSM648820
GEO; GSM1374616
GEO; GSM2069506
GEO; GSM2069507
GEO; GSM2069508
GEO; GSM2069509
GEO; GSM2069510
GEO; GSM2069511
GEO; GSM2069512
GEO; GSM2069513
Other Wikidata; Q29565860
Polymorphism and mutation databases Cosmic; 1330913
Cosmic; 1689711
Cosmic; 2537793
Cosmic; 2580299