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Cellosaurus MDA-PCa-2b (CVCL_4748)

[Text version]

Cell line name MDA-PCa-2b
Synonyms MDA PCa 2b; MDAPCa-2b; MDAPCa2b; MDAPC2B; MDA2B; M.D. Anderson-Prostate Cancer-2b
Accession CVCL_4748
Resource Identification Initiative To cite this cell line use: MDA-PCa-2b (RRID:CVCL_4748)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 42-53 hours (in BRFF-HPC1 + 20% FBS), 61-73 hours (in F12K(+) + 20% FBS) (PubMed=9815652).
Microsatellite instability: Instable (MSI) (PubMed=23671654; PubMed=31068700;).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African90.02
Native American0
East Asian, North2.64
East Asian, South0
South Asian0
European, North0
European, South7.34
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Bone.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4867 (MDA-PCa-2b-hr)
Originate from same individual CVCL_4747 ! MDA-PCa-2a
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=14518029

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,17
D5S81812,13
D7S8208,10
D8S117914,15
D13S31711,12
D16S53910,11
D18S5116,17
D21S1133.2
FGA20,22
TH018,9
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=9815652
Navone N.M., Olive M., Ozen M., Davis R., Troncoso P., Tu S.-M., Johnston D., Pollack A., Pathak S., von Eschenbach A.C., Logothetis C.J.
Establishment of two human prostate cancer cell lines derived from a single bone metastasis.
Clin. Cancer Res. 3:2493-2500(1997)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=15486987; DOI=10.1002/pros.20158
Zhao H., Kim Y., Wang P., Lapointe J., Tibshirani R., Pollack J.R., Brooks J.D.
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-2422
Cell line databases/resources CCLE; MDAPCA2B_PROSTATE
DepMap; ACH-000952
Ontologies BTO; BTO:0005050
CLO; CLO_0007629
Biological sample resources BioSample; SAMN03471841
BioSample; SAMN10988222
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM91928
GEO; GSM648821
GEO; GSM887302
GEO; GSM888377
Other Wikidata; Q54904655
Polymorphism and mutation databases Cosmic; 1689712
Cosmic; 2651771
Cosmic; 2669171
LiGeA; CCLE_281
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number21