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Cellosaurus LNCaP C4-2 (CVCL_4782)

[Text version]
Cell line name LNCaP C4-2
Synonyms LNCaP-C4-2; LNCaP subline C4-2; C4-2; C42; Sp 2817
Accession CVCL_4782
Resource Identification Initiative To cite this cell line use: LNCaP C4-2 (RRID:CVCL_4782)
Comments Population: Caucasian.
Characteristics: Exhibits androgen-independent growth associated with skeletal metastasis, produces metastases when injected either subcutaneously or orthotopically in intact or castrated mice.
Doubling time: 28.96 hours (GrayJW panel).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=26499105).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4783 (LNCaP C4)
Children:
CVCL_4784 (LNCaP C4-2B)CVCL_6E92 (LNCaP C4-2Ln)CVCL_6E93 (LNCaP C4-2Pr)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): PubMed=26499105

Markers:
AmelogeninX,Y
CSF1PO9,10,11,12
D5S81811,12
D7S8209.1,9.3,10.3
D13S31710,11,12
D16S53910,11
TH019
TPOX8,9
vWA16,17,18

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/LNCaP
https://web.archive.org/web/20150602153438/http://capcelllines.ca:80/details.asp?id=52
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-464.html
Publications

PubMed=8169003; DOI=10.1002/ijc.2910570319
Wu H.-C., Hsieh J.-T., Gleave M.E., Brown N.M., Pathak S., Chung L.W.K.
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells.
Int. J. Cancer 57:406-412(1994)

PubMed=15162376; DOI=10.1002/pros.20031
Liu A.Y., Brubaker K.D., Goo Y.A., Quinn J.E., Kral S., Sorensen C.M., Vessella R.L., Belldegrun A.S., Hood L.E.
Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines.
Prostate 60:98-108(2004)

PubMed=26499105; DOI=10.1002/pros.23115
Castanares M.A., Copeland B.T., Chowdhury W.H., Liu M.M., Rodriguez R., Pomper M.G., Lupold S.E., Foss C.A.
Characterization of a novel metastatic prostate cancer cell line of LNCaP origin.
Prostate 76:215-225(2016)

PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065
Abate-Shen C., Nunes de Almeida F.
Establishment of the LNCaP cell line -- the dawn of an era for prostate cancer research.
Cancer Res. 82:1689-1691(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-3314
Cell line databases/resources cancercelllines; CVCL_4782
Anatomy/cell type resources BTO; BTO:0005672
Chemistry resources ChEMBL-Cells; CHEMBL4295439
ChEMBL-Targets; CHEMBL4296460
PubChem_Cell_line; CVCL_4782
Encyclopedic resources Wikidata; Q54902814
Gene expression databases GEO; GSM3145694
Polymorphism and mutation databases Cosmic; 1330914
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27