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Cellosaurus LNCaP C4-2B (CVCL_4784)

[Text version]

Cell line name LNCaP C4-2B
Synonyms C4-2B; C4-2 B; C4-2 Bone metastatic
Accession CVCL_4784
Resource Identification Initiative To cite this cell line use: LNCaP C4-2B (RRID:CVCL_4784)
Comments Characteristics: Bone metastatic.
Doubling time: 24-36 hours (ATCC).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Homozygous for AR p.Thr878Ala (c.2632A>G) (from parent cell line).
Heterozygous for MEN1 p.Tyr313Ter (c.939T>A) (from parent cell line).
Heterozygous for PIK3R1 p.Arg639Ter (c.1915C>T) (from parent cell line).
PTEN p.Lys6Argfs*4 (c.17_18delAA) (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4782 (LNCaP C4-2)
Children:
CVCL_4785 (LNCaP C4-2B2)CVCL_4786 (LNCaP C4-2B3)CVCL_4787 (LNCaP C4-2B4)
CVCL_4788 (LNCaP C4-2B5)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO9,10,11
D5S81811,12
D7S8208.1,9.1,10.3
D13S31710,11
D16S53910,11
TH019
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/LNCaP
Publications

PubMed=8168083
Thalmann G.N., Anezinis P.E., Chang S.-M., Zhau H.E., Kim E.E., Hopwood V.L., Pathak S., von Eschenbach A.C., Chung L.W.K.
Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer.
Cancer Res. 54:2577-2581(1994)

PubMed=15162376; DOI=10.1002/pros.20031
Liu A.Y., Brubaker K.D., Goo Y.A., Quinn J.E., Kral S., Sorensen C.M., Vessella R.L., Belldegrun A.S., Hood L.E.
Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines.
Prostate 60:98-108(2004)

PubMed=24587179; DOI=10.1371/journal.pone.0090002
Spans L., Helsen C., Clinckemalie L., Van den Broeck T., Prekovic S., Joniau S., Lerut E., Claessens F.
Comparative genomic and transcriptomic analyses of LNCaP and C4-2B prostate cancer cell lines.
PLoS ONE 9:E90002-E90002(2014)

DOI=10.1101/2020.03.27.011825
Kohrt S.E., Awadallah W.N., Phillips R.A. III, Case T.C., Jin R., Nanda J.S., Yu X., Clark P.E., Yi Y., Matusik R.J., Anderson P.D., Grabowska M.M.
Identification of genes required for enzalutamide resistance in castration-resistant prostate cancer cells in vitro.
bioRxiv 2020:03.27.011825-03.27.011825(2020)

Cross-references
Cell line collections ATCC; CRL-3315
Ontologies BTO; BTO:0004959
EFO; EFO_0006365
Biological sample resources ENCODE; ENCBS002MOV
ENCODE; ENCBS108UKE
ENCODE; ENCBS109FVF
ENCODE; ENCBS159HRH
ENCODE; ENCBS328CYG
ENCODE; ENCBS391IVJ
ENCODE; ENCBS440KYC
ENCODE; ENCBS582KTC
ENCODE; ENCBS728XMM
ENCODE; ENCBS947VNK
Gene expression databases GEO; GSM648816
Other Wikidata; Q54902815
Polymorphism and mutation databases Cosmic; 1689709
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number20