| Cell line name |
LNCaP-abl |
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| Synonyms |
LNCaP-androgen ablation |
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| Accession |
CVCL_4793 |
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| Resource Identification Initiative |
To cite this cell line use: LNCaP-abl (RRID:CVCL_4793) |
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| Comments |
Population: Caucasian.
Characteristics: Established after 10 months of propagation of LNCaP in steroid-depleted medium.
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptome analysis by RNAseq.
Misspelling: LNCaP-abI; BTO=BTO:0006467.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0395 (LNCaP) |
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| Sex of cell |
Male |
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| Age at sampling |
50Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=10496349; DOI=10.1038/sj.bjc.6690684
Culig Z., Hoffmann J., Erdel M., Eder I.E., Hobisch A., Hittmair A., Bartsch G., Utermann G., Schneider M.R., Parczyk K., Klocker H.
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system.
Br. J. Cancer 81:242-251(1999) PubMed=34402095; DOI=10.1002/pros.24210
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J.L., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4793
|
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| Anatomy/cell type resources |
BTO; BTO:0006467
|
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| Encyclopedic resources |
Wikidata; Q54902830
|
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| Gene expression databases |
GEO; GSM3145719
GEO; GSM5402195
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 23 |
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