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Cellosaurus LNCaP-abl (CVCL_4793)

[Text version]

Cell line name LNCaP-abl
Synonyms LNCaP-androgen ablation
Accession CVCL_4793
Resource Identification Initiative To cite this cell line use: LNCaP-abl (RRID:CVCL_4793)
Comments Characteristics: Established after 10 months of propagation of LNCaP in steroid-depleted medium.
Karyotypic information: Has lost chromosome Y.
Omics: Deep RNAseq analysis.
Misspelling: LNCaP-abI; In BTO BTO:0006467.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10496349; DOI=10.1038/sj.bjc.6690684
Culig Z., Hoffmann J., Erdel M., Eder I.E., Hobisch A., Hittmair A., Bartsch G., Utermann G., Schneider M.R., Parczyk K., Klocker H.
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system.
Br. J. Cancer 81:242-251(1999)

DOI=10.1101/2021.07.04.450352
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration resistant prostate cancer.
bioRxiv 2021:07.04.450352-07.04.450352(2021)

Cross-references
Anatomy/cell type resources BTO; BTO:0006467
Encyclopedic resources Wikidata; Q54902830
Gene expression databases GEO; GSM5402195
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number18