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Cellosaurus CWR-R1 (CVCL_4833)

[Text version]

Cell line name CWR-R1
Accession CVCL_4833
Resource Identification Initiative To cite this cell line use: CWR-R1 (RRID:CVCL_4833)
Comments Characteristics: Co-culture of polygonal closely aggregated epithelial cells surrounded by bipolar stromal fibroblasts.
Doubling time: 33.57 hours (https://www.synapse.org/#!Synapse:syn2347014).
Omics: Transcriptome analysis.
Derived from sampling site: Prostate.
Sequence variations
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3967 (CWR22)
CVCL_ZC60 (CWR-R1-AD1 )CVCL_RA55 (CWR-R1-EnzR )CVCL_LI36 (CWR-R1ca )
CVCL_LI37 (CWR-R1fb )
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): PubMed=14518029


Run an STR similarity search on this cell line

Gregory C.W., Johnson R.T. Jr., Mohler J.L., French F.S., Wilson E.M.
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
Cancer Res. 61:2892-2898(2001)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
van Bokhoven A., Caires A., Maria M.D., Schulte A.P., Lucia M.S., Nordeen S.K., Miller G.J., Varella-Garcia M.
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630
Li Y., Chan S.-C., Brand L.J., Hwang T.H., Silverstein K.A.T., Dehm S.M.
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=27036029; DOI=10.18632/oncotarget.8456
Kregel S., Chen J.L., Tom W., Krishnan V., Kach J., Brechka H., Fessenden T.B., Isikbay M., Paner G.P., Szmulewitz R.Z., Vander Griend D.J.
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

PubMed=27271795; DOI=10.1002/pros.23190
Shourideh M., DePriest A., Mohler J.L., Wilson E.M., Koochekpour S.
Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.
Prostate 76:1067-1077(2016)

Cell line collections Kerafast; ENC005
Encyclopedic resources Wikidata; Q54817049
Gene expression databases GEO; GSM2069498
GEO; GSM2069499
GEO; GSM2069500
GEO; GSM2069501
GEO; GSM2069502
GEO; GSM2069503
GEO; GSM2069504
GEO; GSM2069505
Polymorphism and mutation databases IARC_TP53; 18888
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number17