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Cellosaurus PK-59 (CVCL_4897)

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Cell line name PK-59
Synonyms PK59
Accession CVCL_4897
Resource Identification Initiative To cite this cell line use: PK-59 (RRID:CVCL_4897)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 52 hours (PubMed=7622937).
Omics: Deep RNAseq analysis.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations KRAS p.Gly12Asp (c.35G>A) (PubMed=11115575; PubMed=22490663).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.12
East Asian, North83.8
East Asian, South14.64
South Asian0
European, North0
European, South1.44
Disease Pancreatic carcinoma (NCIt: C3850)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0B32 (RPK-59)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO10
D3S135818
D5S81811
D7S8208
D8S117911
D13S31710,12
D16S53911,12
D18S5113
D21S1130,31
FGA19
Penta D8,11
Penta E16,22
TH018,9
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=7622937; DOI=10.1007/BF02788531
Amikura K., Kobari M., Matsuno S.
The time of occurrence of liver metastasis in carcinoma of the pancreas.
Int. J. Pancreatol. 17:139-146(1995)

PubMed=11115575; DOI=10.3892/or.8.1.89
Sun C., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections RCB; RCB1901
TKG; TKG 0492
Cell line databases/resources CCLE; PK59_PANCREAS
Ontologies BTO; BTO:0005487
CLO; CLO_0050100
EFO; EFO_0006736
Biological sample resources BioSample; SAMN03472950
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM862572
GEO; GSM862574
GEO; GSM887517
GEO; GSM888599
GEO; GSM1588611
GEO; GSM1588623
Other Wikidata; Q54947453
Polymorphism and mutation databases Cosmic; 707257
Cosmic; 1066186
Cosmic; 1299305
Cosmic; 1644306
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number19