Cellosaurus PK-59 (CVCL_4897)

Cell line name PK-59
Synonyms PK59
Accession CVCL_4897
Resource Identification Initiative To cite this cell line use: PK-59 (RRID:CVCL_4897)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep RNAseq analysis.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Pancreatic carcinoma (NCIt: C3850)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_0B32 (RPK-59)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO10
D13S31710,12
D16S53911,12
D18S5113
D21S1130,31
D3S135818
D5S81811
D7S8208
D8S117911
FGA19
Penta D8,11
Penta E16,22
TH018,9
TPOX8,11
vWA18
Publications

PubMed=7622937; DOI=10.1007/BF02788531
Amikura K., Kobari M., Matsuno S.
The time of occurrence of liver metastasis in carcinoma of the pancreas.
Int. J. Pancreatol. 17:139-146(1995)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

Cross-references
Cell line collections RCB; RCB1901
TKG; TKG 0492
Cell line databases/resources CCLE; PK59_PANCREAS
Ontologies BTO; BTO:0005487
CLO; CLO_0050100
EFO; EFO_0006736
Biological sample resources BioSample; SAMN03472950
Gene expression databases GEO; GSM887517
GEO; GSM888599
GEO; GSM1588611
Polymorphism and mutation databases Cosmic; 707257
Cosmic; 1066186
Cosmic; 1299305
Cosmic; 1644306