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Cellosaurus SSP-25 (CVCL_4902)

Cell line name SSP-25
Synonyms SSP25
Accession CVCL_4902
Resource Identification Initiative To cite this cell line use: SSP-25 (RRID:CVCL_4902)
Comments Problematic cell line: Contaminated. Shown to be a ETK-1 derivative (RCB=RCB1293). Originally thought to originate from a 64 year old female patient with an intrahepatic cholangiocarcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Population: Japanese.
Doubling time: 64 hours (PubMed=9358283).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Intrahepatic cholangiocarcinoma (NCIt: C35417)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1206 (ETK-1)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): DepMap; RCB

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81810
D7S82011
D8S117910,12
D13S31712
D16S53910,12
D18S5121
D21S1129
FGA19,25
Penta D14
Penta E15
TH017,9.3
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Web pages https://cell.brc.riken.jp/en/rcb/rbessp-25_announce
Publications

PubMed=9358283; DOI=10.1007/s11626-997-0125-z
Enjoji M., Sakai H., Nawata H., Kajiyama K., Tsuneyoshi M.
Sarcomatous and adenocarcinoma cell lines from the same nodule of cholangiocarcinoma.
In Vitro Cell. Dev. Biol. Anim. 33:681-683(1997)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., El-Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

Cross-references
Cell line collections (Providers) RCB; RCB1293
Cell line databases/resources CLO; CLO_0050849
Cell_Model_Passport; SIDM00275
DepMap; ACH-001858
Biological sample resources BioSample; SAMN03472126
Encyclopedic resources Wikidata; Q54955717
Polymorphism and mutation databases Cosmic; 1187339
Cosmic; 1571786
Cosmic; 2629287
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number27