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Cellosaurus KOPT-K1 (CVCL_4965)

[Text version]

Cell line name KOPT-K1
Synonyms KOPT-KI; KOPTK-1; KOPTK1; KopTK1; Koptk1
Accession CVCL_4965
Resource Identification Initiative To cite this cell line use: KOPT-K1 (RRID:CVCL_4965)
Sequence variations Heterozygous for NOTCH1 p.Leu1600Pro (c.4799T>C) and p.Pro2514fs*4 (c.7541_7542delCT) (PubMed=15472075).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
Publications

PubMed=7475267
Dong W.-F., Xu Y., Hu Q.L., Munroe D., Minowada J., Housman D.E., Minden M.D.
Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1.
Leukemia 9:1812-1817(1995)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Kawamura M., Ohnishi H., Guo S.X., Sheng X.-M., Minegishi M., Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M., Sekiya T., Hayashi Y.
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10360377; DOI=10.1038/sj.leu.2401437
Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T., Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K., O-Koyama T., Mori T., Nakazawa S.
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.
Leukemia 13:884-890(1999)

PubMed=10995006; DOI=10.1038/sj.leu.2401893
Iijima K., Sugita K., Inukai T., Goi K., Tezuka T., Uno K., Sato H., Kagami K., Nakazawa S.
Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome.
Leukemia 14:1598-1605(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H., Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H., Akahane K., Zhang X., Kuroda I., Honna H., Kagami K., Goi K., Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

Cross-references
Ontologies BTO; BTO:0004964
EFO; EFO_0006283
Biological sample resources ENCODE; ENCBS345YKN
ENCODE; ENCBS869LIS
Other Wikidata; Q54900335
Polymorphism and mutation databases Cosmic; 721714
Cosmic; 913407
Cosmic; 944545
Cosmic; 998730
Cosmic; 1037683
Cosmic; 1115584
Cosmic; 1151783
Cosmic; 1224374
Cosmic; 1524801
Cosmic; 1641389
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-20
Version number11