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Cellosaurus MHCC97-H (CVCL_4972)

Cell line name MHCC97-H
Synonyms MHCC 97-H; MHCC-97H; MHCC97H
Accession CVCL_4972
Resource Identification Initiative To cite this cell line use: MHCC97-H (RRID:CVCL_4972)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Chinese.
Characteristics: High metastatic potential.
Doubling time: 28.79 hours (PubMed=31378681).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Deep exome analysis.
Omics: Deep phosphoproteome analysis.
Omics: Genome sequenced.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 14310; BRD7; Simple; p.Glu277Glyfs*18 (c.830_831delAG); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; 23177; KEAP1; Simple; p.Pro445Glnfs*13 (c.1334delC); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4971 (MHCC97)
CVCL_6832 (HCCLM3)CVCL_VU22 (MHCC97-H c-Met shRNA)CVCL_VU23 (MHCC97-H CD44s shRNA)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=31378681


Run an STR similarity search on this cell line
Web pages https://lccl.zucmanlab.com/hcc/cellLines/MHCC97H

PubMed=11819844; DOI=10.3748/wjg.v7.i5.630
Li Y., Tang Z.-Y., Ye S.-L., Liu Y.-K., Chen J., Xue Q., Chen J., Gao D.-M., Bao W.-H.
Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97.
World J. Gastroenterol. 7:630-636(2001)

PubMed=15048980; DOI=10.1002/pmic.200300653
Ding S.-J., Li Y., Shao X.-X., Zhou H., Zeng R., Tang Z.-Y., Xia Q.-C.
Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials.
Proteomics 4:982-994(2004)

PubMed=15146329; DOI=10.1007/s00432-004-0564-9
Li Y., Tian B., Yang J., Zhao L., Wu X., Ye S.-L., Liu Y.-K., Tang Z.-Y.
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics.
J. Cancer Res. Clin. Oncol. 130:460-468(2004)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=25690035; DOI=10.3390/ijms16024209
Tian M.-M., Cheng H., Wang Z.-Q., Su N., Liu Z.-X., Sun C.-Q., Zhen B., Hong X.-C., Xue Y., Xu P.
Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.
Int. J. Mol. Sci. 16:4209-4225(2015)

PubMed=25886575; DOI=10.1186/s12885-015-1166-4
Dang H., Steinway S.N., Ding W., Rountree C.B.
Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma.
BMC Cancer 15:161.1-161.11(2015)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

PubMed=32884988; DOI=10.1016/j.gendis.2019.12.008
Lin Y.-L., Li Y.
Study on the hepatocellular carcinoma model with metastasis.
Genes Dis. 7:336-350(2020)

Cell line databases/resources cancercelllines; CVCL_4972
Anatomy/cell type resources BTO; BTO:0004169
Chemistry resources ChEMBL-Cells; CHEMBL4295459
ChEMBL-Targets; CHEMBL4296470
PubChem_Cell_line; CVCL_4972
Encyclopedic resources Wikidata; Q54905533
Gene expression databases GEO; GSM501782
GEO; GSM936771
GEO; GSM1374675
GEO; GSM2551579
Proteomic databases PRIDE; PXD000529
PRIDE; PXD000533
PRIDE; PXD000535
PRIDE; PXD002453
PRIDE; PXD005291
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number20