Home  |  Contact

Cellosaurus SKO-007 (CVCL_4974)

[Text version]

Cell line name SKO-007
Synonyms SKO007; U-226AR1; U-266 AR1
Accession CVCL_4974
Resource Identification Initiative To cite this cell line use: SKO-007 (RRID:CVCL_4974)
Comments Group: Hybridoma fusion partner cell line.
Characteristics: Produces IgE lambda.
Selected for resistance to: ChEBI; CHEBI:63486; 8-azaguanine.
Omics: SNP array analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BRAF p.Lys601Asn (c.1803A>T) (from parent cell line).
Heterozygous for MSH6 p.Gly141Asp (c.422G>A) (from parent cell line).
Homozygous for TP53 p.Ala161Thr (c.481G>A) (ClinVar=VCV000161518) (from parent cell line).
Homozygous for TRAF3 p.Lys550Leufs*3 (c.1648_1649insT) (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Children:
CVCL_4975 (SKO-007 clone J3)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO12,13
D5S81811,12
D7S82011,12
D13S31712
D16S53910
TH015,7
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=6159646; DOI=10.1073/pnas.77.9.5429
Olsson L., Kaplan H.S.
Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
Proc. Natl. Acad. Sci. U.S.A. 77:5429-5431(1980)

PubMed=6864164; DOI=10.1084/jem.158.1.53
Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F., Old L.J.
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections ATCC; CRL-8033-1
Cell line databases/resources IGRhCellID; SKO007
Ontologies CLO; CLO_0009061
EFO; EFO_0002339
Other Wikidata; Q54954759
Polymorphism and mutation databases Cosmic; 2159572
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number16