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Cellosaurus GIST-T1 (CVCL_4976)

[Text version]

Cell line name GIST-T1
Synonyms GIST-T-1; GISTT1; T1
Accession CVCL_4976
Resource Identification Initiative To cite this cell line use: GIST-T1 (RRID:CVCL_4976)
Comments Population: Japanese.
Doubling time: 48 hours (PubMed=12004007).
Omics: ATAC-seq.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Deep tyrosine phosphoproteome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=12004007; PubMed=16077968).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QW91 (GIST-T1-117)CVCL_QW82 (GIST-T1-R2)CVCL_QW86 (GIST-T1-R8)
CVCL_QW90 (GIST-T1-R9)CVCL_QW89 (GIST-T1-RA2)CVCL_A9M9 (GIST-T1/670)
CVCL_A9N0 (GIST-T1/816)CVCL_S983 (GIST-T1/829)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages https://www.cosmobio.com/contents/gist-t1_culture_kit.html
Publications

PubMed=12004007; DOI=10.1038/labinvest.3780461
Taguchi T., Sonobe H., Toyonaga S.-I., Yamasaki I., Shuin T., Takano A., Araki K., Akimaru K., Yuri K.
Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor.
Lab. Invest. 82:663-665(2002)

PubMed=16077968; DOI=10.3892/or.14.3.645
Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol. Rep. 14:645-650(2005)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=22665524; DOI=10.1158/1535-7163.MCT-12-0223
Heinrich M.C., Marino-Enriquez A., Presnell A., Donsky R.S., Griffith D.J., McKinley A., Patterson J., Taguchi T., Liang C.-W., Fletcher J.A.
Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.
Mol. Cancer Ther. 11:1770-1780(2012)

PubMed=23716303; DOI=10.1002/ijc.28282
Takahashi T., Serada S., Ako M., Fujimoto M., Miyazaki Y., Nakatsuka R., Ikezoe T., Yokoyama A., Taguchi T., Shimada K., Kurokawa Y., Yamasaki M., Miyata H., Nakajima K., Takiguchi S., Mori M., Doki Y., Naka T., Nishida T.
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
Int. J. Cancer 133:2737-2743(2013)

PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397
Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A., Zhou T., Serrano C., Eilers G., Zhu M., Ketzer J., Wardwell S., Ning Y., Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., Fletcher J.A., Bauer S., Rivera V.M.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin. Cancer Res. 20:5745-5755(2014)

PubMed=27997714; DOI=10.1002/gcc.22438
Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R., Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T., Tsuchihara K., Nishida T., Kato M.
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)

PubMed=29866822; DOI=10.1073/pnas.1802079115
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=32736695; DOI=10.1016/j.bbrc.2020.05.174
Cho W.-C., Shin Y.-K., Na Y.-S., Ryu M.-H., Ku J.-L., Kang Y.-K.
The role of novel fusion genes in human GIST cell lines derived from imatinib-resistant GIST patients: a therapeutic potential of fusion gene.
Biochem. Biophys. Res. Commun. 529:699-706(2020)

Cross-references
Cell line databases/resources DepMap; ACH-002332
Gene expression databases GEO; GSM1701539
GEO; GSM2527248
GEO; GSM2527250
GEO; GSM2527251
GEO; GSM2527316
GEO; GSM2527317
GEO; GSM2527318
GEO; GSM2527319
GEO; GSM3070588
Other Wikidata; Q54835846
Polymorphism and mutation databases Cosmic; 1029465
Cosmic; 1873953
Cosmic; 2607430
Cosmic; 2805388
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number12