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Cellosaurus GIST-T1 (CVCL_4976)

[Text version]

Cell line name GIST-T1
Synonyms GIST-T-1; GISTT1; T1
Accession CVCL_4976
Resource Identification Initiative To cite this cell line use: GIST-T1 (RRID:CVCL_4976)
Comments Doubling time: 48 hours (PubMed=12004007).
Omics: Deep exome analysis.
Omics: Deep tyrosine phosphoproteome analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KIT p.Val560_Tyr578del (PubMed=12004007; PubMed=16077968).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QW91 (GIST-T1-117)CVCL_QW82 (GIST-T1-R2)CVCL_QW86 (GIST-T1-R8)
CVCL_QW90 (GIST-T1-R9)CVCL_QW89 (GIST-T1-RA2)CVCL_S983 (GIST-T1/829)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Web pages https://www.cosmobio.com/contents/gist-t1_culture_kit.html
Publications

PubMed=12004007; DOI=10.1038/labinvest.3780461
Taguchi T., Sonobe H., Toyonaga S.-I., Yamasaki I., Shuin T., Takano A., Araki K., Akimaru K., Yuri K.
Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor.
Lab. Invest. 82:663-665(2002)

PubMed=16077968; DOI=10.3892/or.14.3.645
Noma K., Naomoto Y., Gunduz M., Matsuoka J., Yamatsuji T., Shirakawa Y., Nobuhisa T., Okawa T., Takaoka M., Tomono Y., Hiroyuki O., Gunduz E., Tanaka N.
Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.
Oncol. Rep. 14:645-650(2005)

PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004
Muhlenberg T., Zhang Y., Wagner A.J., Grabellus F., Bradner J., Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Cancer Res. 69:6941-6950(2009)

PubMed=23716303; DOI=10.1002/ijc.28282
Takahashi T., Serada S., Ako M., Fujimoto M., Miyazaki Y., Nakatsuka R., Ikezoe T., Yokoyama A., Taguchi T., Shimada K., Kurokawa Y., Yamasaki M., Miyata H., Nakajima K., Takiguchi S., Mori M., Doki Y., Naka T., Nishida T.
New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.
Int. J. Cancer 133:2737-2743(2013)

PubMed=27997714; DOI=10.1002/gcc.22438
Takahashi T., Elzawahry A., Mimaki S., Furukawa E., Nakatsuka R., Nakamura H., Nishigaki T., Serada S., Naka T., Hirota S., Shibata T., Tsuchihara K., Nishida T., Kato M.
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Genes Chromosomes Cancer 56:303-313(2017)

Cross-references
Gene expression databases GEO; GSM1701539
Other Wikidata; Q54835846
Polymorphism and mutation databases Cosmic; 1029465
Cosmic; 1873953
Cosmic; 2607430
Entry history
Entry creation04-Apr-2012
Last entry updated07-Sep-2018
Version number8