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Cellosaurus U-CH2 (CVCL_4989)

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Cell line name U-CH2
Synonyms UCH2
Accession CVCL_4989
Resource Identification Initiative To cite this cell line use: U-CH2 (RRID:CVCL_4989)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 4 days (PubMed=26183925); ~5-7 days (DSMZ); 3 days (Chordoma_Foundation).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis.
HLA typing Source: Chordoma_Foundation
Class I
HLA-AA*11:01
HLA-BB*07
HLA-CC*07:02
Class II
HLA-DQDQA1*02:01
DQB1*03
HLA-DRDRB4*01:03N
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.92
East Asian, North0
East Asian, South0.34
South Asian1.36
European, North67.93
European, South29.44
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=21253487; PubMed=26183925; PubMed=27102572; PubMed=28835717

Markers:
AmelogeninX
CSF1PO11,12
D1S165614.3,15
D2S44110,11.3
D2S133824
D3S135817
D5S81810,11
D7S8208,12
D8S117913
D10S124813,16
D12S39118,19
D13S31711
D16S53912
D18S5112,18
D19S43315.2,17
D21S1129,30
D22S104515
FGA21,22.2
Penta D12,13
Penta E12,15
TH019.3 (ATCC; DSMZ; PubMed=26183925; PubMed=27102572)
6 (Cosmic-CLP)
6,9.3 (PubMed=21253487)
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages https://www.chordomafoundation.org/research/disease-models/u-ch2/
http://genome.ucsc.edu/ENCODE/protocols/cell/human/UCH1_Crawford_protocol.pdf
Publications

PubMed=21253487; DOI=10.1155/2010/630129
Bruderlein S., Sommer J.B., Meltzer P.S., Li S., Osada T., Ng D., Moller P., Alcorta D.A., Kelley M.J.
Molecular characterization of putative chordoma cell lines.
Sarcoma 2010:630129-630129(2010)

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., Baer A.V., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

PubMed=28835717; DOI=10.1038/s41598-017-10044-3
Bosotti R., Magnaghi P., Di Bella S., Cozzi L., Cusi C., Bozzi F., Beltrami N., Carapezza G., Ballinari D., Amboldi N., Lupi R., Somaschini A., Raddrizzani L., Salom B., Galvani A., Stacchiotti S., Tamborini E., Isacchi A.
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.
Sci. Rep. 7:9226-9226(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-3218
DSMZ; ACC-749
Cell line databases/resources CCLE; UCH2_BONE
Cell_Model_Passport; SIDM01185
Cosmic-CLP; 1503373
DepMap; ACH-002204
Chemistry resources PharmacoDB; UCH2_1627_2019
Gene expression databases GEO; GSM1670565
GEO; GSM1673847
GEO; GSM1673848
Other Wikidata; Q54973617
Polymorphism and mutation databases Cosmic; 2663858
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number22