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Cellosaurus MS751 (CVCL_4996)

Cell line name MS751
Synonyms MS-751; MS 751
Accession CVCL_4996
Resource Identification Initiative To cite this cell line use: MS751 (RRID:CVCL_4996)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Contains a partial HPV45 genome.
Doubling time: 2.4 days (PubMed=29156801).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Transformant: NCBI_TaxID; 10593; Human papillomavirus type 45 (HPV45).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200; PubMed=29156801

Markers:
AmelogeninX
CSF1PO11,12 (ATCC; Cosmic-CLP; PubMed=29156801)
11 (PubMed=25877200)
D2S133822
D3S135819
D5S81812
D7S8209,11
D8S117914
D13S31712
D16S53911
D18S5112
D19S43316
D21S1129,30
FGA20
Penta D9
Penta E12
TH016
TPOX8
vWA16
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2990217
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=9049418; DOI=10.1099/0022-1317-78-3-655
Geisbill J., Osmers U., Durst M.
Detection and characterization of human papillomavirus type 45 DNA in the cervical carcinoma cell line MS751.
J. Gen. Virol. 78:655-658(1997)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections ATCC; HTB-34
Cell line databases/resources CCLE; MS751_CERVIX
Cosmic-CLP; 1240179
GDSC; 1240179
IGRhCellID; MS751
LINCS_LDP; LCL-1306
Ontologies CLO; CLO_0007878
EFO; EFO_0006456
Biological sample resources BioSample; SAMN03472742
BioSample; SAMN03473089
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM113865
GEO; GSM253301
GEO; GSM675737
GEO; GSM685439
GEO; GSM1670135
Other Wikidata; Q54906811
Polymorphism and mutation databases Cosmic; 928910
Cosmic; 1071904
Cosmic; 1131523
Cosmic; 1176606
Cosmic; 1193034
Cosmic; 1201772
Cosmic; 1995514