Cellosaurus cell line GLC-4/ADR (CVCL_4997)

• Mutation; HGNC; 11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
  

PubMed=3028613
Zijlstra J.G., de Vries E.G.E., Mulder N.H.
Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.
Cancer Res. 47:1780-1784(1987)

PubMed=3040227
Meijer C., Mulder N.H., Timmer-Bosscha H., Zijlstra J.G., de Vries E.G.E.
Role of free radicals in an adriamycin-resistant human small cell lung cancer cell line.
Cancer Res. 47:4613-4617(1987)

PubMed=1657425; DOI=10.1007/BF00685823
de Jong S., Zijlstra J.G., Mulder N.H., de Vries E.G.E.
Lack of cross-resistance to fostriecin in a human small-cell lung carcinoma cell line showing topoisomerase II-related drug resistance.
Cancer Chemother. Pharmacol. 28:461-464(1991)

PubMed=7809167; DOI=10.1073/pnas.91.26.13033
Muller M., Meijer C., Zaman G.J.R., Borst P., Scheper R.J., Mulder N.H., de Vries E.G.E., Jansen P.L.M.
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994)

PubMed=7729950; DOI=10.1002/ijc.2910610317
Versantvoort C.H.M., Withoff S., Broxterman H.J., Kuiper C.M., Scheper R.J., Mulder N.H., de Vries E.G.E.
Resistance-associated factors in human small-cell lung-carcinoma GLC4 sub-lines with increasing adriamycin resistance.
Int. J. Cancer 61:375-380(1995)

PubMed=8980384; DOI=10.1038/bjc.1996.647
Withoff S., de Vries E.G.E., Keith W.N., Nienhuis E.F., van der Graaf W.T.A., Uges D.R.A., Mulder N.H.
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Br. J. Cancer 74:1869-1876(1996)

PubMed=11309308
Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A., Pijnenborg A.C.L.M., Schinkel A.H., van de Vijver M.J., Scheper R.J., Schellens J.H.M.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer Res. 61:3458-3464(2001)