ID   MCF-7/CG-5
AC   CVCL_4D04
SY   CG-5; CG5
DR   CLO; CLO_0002398
DR   cancercelllines; CVCL_4D04
DR   Wikidata; Q54904360
RX   PubMed=3516389;
RX   PubMed=6575841;
RX   PubMed=8712686;
CC   Population: Caucasian.
CC   Characteristics: Estrogen supersensitive (PubMed=6575841).
CC   Doubling time: 13 hours (PubMed=8712686).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 05-10-23; Version: 15
//
RX   PubMed=3516389;
RA   Iacobelli S., Arno E., D'Orazio A., Coletti G.;
RT   "Detection of antigens recognized by a novel monoclonal antibody in
RT   tissue and serum from patients with breast cancer.";
RL   Cancer Res. 46:3005-3010(1986).
//
RX   PubMed=6575841; DOI=10.1007/BF01806231;
RA   Natoli C., Sica G., Natoli V., Serra A., Iacobelli S.;
RT   "Two new estrogen-supersensitive variants of the MCF-7 human breast
RT   cancer cell line.";
RL   Breast Cancer Res. Treat. 3:23-32(1983).
//
RX   PubMed=8712686;
RA   Gibelli N., Zibera C., Asti A., Maestri L., Bacchella L.,
RA   Pedrazzoli P., Calligaro A., Robustelli della Cuna G.;
RT   "CG5/Dx human breast cancer cell line: characterization of a new
RT   doxorubicin-resistant variant.";
RL   Anticancer Res. 16:1675-1681(1996).
//