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Cellosaurus MCF-7/CG-5/Dx (CVCL_4D05)

[Text version]
Cell line name MCF-7/CG-5/Dx
Synonyms CG5/Dx
Accession CVCL_4D05
Resource Identification Initiative To cite this cell line use: MCF-7/CG-5/Dx (RRID:CVCL_4D05)
Comments Population: Caucasian.
Doubling time: 47 hours (PubMed=8712686).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4D04 (MCF-7/CG-5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8712686
Gibelli N., Zibera C., Asti A., Maestri L., Bacchella L., Pedrazzoli P., Calligaro A., Robustelli della Cuna G.
CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.
Anticancer Res. 16:1675-1681(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4D05
Encyclopedic resources Wikidata; Q54811574
Entry history
Entry creation22-Sep-2015
Last entry update05-Oct-2023
Version number15