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Cellosaurus MP46 (CVCL_4D13)

[Text version]
Cell line name MP46
Accession CVCL_4D13
Resource Identification Initiative To cite this cell line use: MP46 (RRID:CVCL_4D13)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft.
Doubling time: 110 hours (PubMed=24994677).
Omics: SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
  • Mutation; HGNC; 4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=24994677).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ATCC; DepMap; PubMed=24994677

Markers:
AmelogeninX
CSF1PO11
D3S135818
D5S81812
D7S82011
D8S117911,12,15
D13S31710,12
D16S53912
D18S5113
D21S1130,31
FGA22,22.2,24
Penta D9,12
Penta E12
TH019
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004
Amirouchene-Angelozzi N., Nemati F., Gentien D., Nicolas A., Dumont A., Carita G., Camonis J., Desjardins L., Cassoux N., Piperno-Neumann S., Mariani P., Sastre X., Decaudin D., Roman-Roman S.
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

Cross-references
Cell line collections (Providers) ATCC; CRL-3298
Cell line databases/resources cancercelllines; CVCL_4D13
Cell_Model_Passport; SIDM01789
DepMap; ACH-002011
Encyclopedic resources Wikidata; Q54906430
Entry history
Entry creation22-Sep-2015
Last entry update05-Oct-2023
Version number10