ID   KM12-LX
AC   CVCL_4M94
SY   KM12LX
DR   cancercelllines; CVCL_4M94
DR   Wikidata; Q54900060
RX   PubMed=1679016;
RX   PubMed=7529188;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 8031; NTRK1 + HGNC; 12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9547 ! KM12-C
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 05-10-23; Version: 13
//
RX   PubMed=1679016; DOI=10.1016/0014-4827(91)90451-Y;
RA   Matsushita Y., Nakamori S., Seftor E.A., Hendrix M.J.C., Irimura T.;
RT   "Human colon carcinoma cells with increased invasive capacity obtained
RT   by selection for sialyl-dimeric LeX antigen.";
RL   Exp. Cell Res. 196:20-25(1991).
//
RX   PubMed=7529188; DOI=10.1006/excr.1995.1027;
RA   Izumi Y., Taniuchi Y., Tsuji T., Smith C.W., Nakamori S., Fidler I.J.,
RA   Irimura T.;
RT   "Characterization of human colon carcinoma variant cells selected for
RT   sialyl Lex carbohydrate antigen: liver colonization and adhesion to
RT   vascular endothelial cells.";
RL   Exp. Cell Res. 216:215-221(1995).
//