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Cellosaurus MES-SA/DxP5002 (CVCL_4T94)

[Text version]
Cell line name MES-SA/DxP5002
Synonyms DxP
Accession CVCL_4T94
Resource Identification Initiative To cite this cell line use: MES-SA/DxP5002 (RRID:CVCL_4T94)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT); ClinVar=VCV000428208; Zygosity=Heterozygous (from parent cell line).
Disease Uterine corpus sarcoma (NCIt: C6339)
Sarcoma of the corpus uteri (ORDO: Orphanet_213620)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2598 (MES-SA/Dx5)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=9038218; DOI=10.1074/jbc.272.9.5974
Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.-P., Dumontet C., Sikic B.I.
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
J. Biol. Chem. 272:5974-5982(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4T94
Encyclopedic resources Wikidata; Q54905251
Entry history
Entry creation22-Sep-2015
Last entry update05-Oct-2023
Version number9