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Cellosaurus H1650-ER1 (CVCL_4V01)

[Text version]
Cell line name H1650-ER1
Accession CVCL_4V01
Resource Identification Initiative To cite this cell line use: H1650-ER1 (RRID:CVCL_4V01)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.673-2A>G (IVS6-2A>G); ClinVar=VCV000458555; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1483 (NCI-H1650)
Sex of cell Male
Age at sampling 27Y
Category Cancer cell line
Publications

PubMed=22433462; DOI=10.1186/1471-2407-12-95
Ghosh G., Lian X.-J., Kron S.J., Palecek S.P.
Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.
BMC Cancer 12:95.1-95.14(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V01
Encyclopedic resources Wikidata; Q54871955
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number12