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Cellosaurus CEM-VLB (CVCL_4V08)

[Text version]

Cell line name CEM-VLB
Accession CVCL_4V08
Resource Identification Initiative To cite this cell line use: CEM-VLB (RRID:CVCL_4V08)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27375; Vincaleukoblastine (Vinblastine).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=11801309; DOI=10.1016/S0165-4608(01)00519-2
Struski S., Cornillet-Lefebvre P., Doco-Fenzy M., Dufer J., Ulrich E., Masson L., Michel N., Gruson N., Potron G.
Cytogenetic characterization of chromosomal rearrangement in a human vinblastine-resistant CEM cell line: use of comparative genomic hybridization and fluorescence in situ hybridization.
Cancer Genet. Cytogenet. 132:51-54(2002)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307645
ChEMBL-Targets; CHEMBL614554
Encyclopedic resources Wikidata; Q54809261
Entry history
Entry creation14-Dec-2015
Last entry update23-Jun-2022
Version number13