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Cellosaurus U937/ara-C (CVCL_4V23)

[Text version]

Cell line name U937/ara-C
Accession CVCL_4V23
Resource Identification Initiative To cite this cell line use: U937/ara-C (RRID:CVCL_4V23)
Comments Selected for resistance to: ChEBI; CHEBI:28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=21290089; DOI=10.3892/ijo.2011.933
Negoro E., Yamauchi T., Urasaki Y., Nishi R., Hori H., Ueda T.
Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses.
Int. J. Oncol. 38:911-919(2011)

Cross-references
Other Wikidata; Q54973777
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number6