Cell line name |
U937/ara-C |
Accession |
CVCL_4V23 |
Resource Identification Initiative |
To cite this cell line use: U937/ara-C (RRID:CVCL_4V23) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:28680; Cytarabine (Arabinosylcytosine; Ara-C). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | PubMed=21290089; DOI=10.3892/ijo.2011.933 Negoro E., Yamauchi T., Urasaki Y., Nishi R., Hori H., Ueda T. Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38:911-919(2011) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_4V23
|
Encyclopedic resources |
Wikidata; Q54973777
|
Entry history |
Entry creation | 14-Dec-2015 |
Last entry update | 05-Oct-2023 |
Version number | 13 |
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