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Cellosaurus MCF-7/TPT300 (CVCL_4V42)

[Text version]
Cell line name MCF-7/TPT300
Synonyms MCF7/TPT300
Accession CVCL_4V42
Resource Identification Initiative To cite this cell line use: MCF-7/TPT300 (RRID:CVCL_4V42)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:63632; Topotecan.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=10930538; DOI=10.1016/S0006-2952(00)00396-8
Yang C.-H., Schneider E., Kuo M.-L., Volk E.L., Rocchi E., Chen Y.-C.
BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells.
Biochem. Pharmacol. 60:831-837(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V42
Encyclopedic resources Wikidata; Q54904395
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number13